Evidence map›Paper›PMID 37253743›Full record

ArticleNature communications2023

Afferent convergence to a shared population of interneuron AMPA receptors.

Reagan L Pennock, Luke T Coddington, Xiaohui Yan, Linda Overstreet-Wadiche, Jacques I Wadiche

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Reagan L PennockDepartment of Neurobiology, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.ORCID 0000-0003-3976-4641
Luke T CoddingtonDepartment of Neurobiology, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.ORCID 0000-0002-0785-4231
Xiaohui YanDepartment of Neurobiology, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.ORCID 0000-0002-5220-7148
Linda Overstreet-WadicheDepartment of Neurobiology, University of Alabama at Birmingham, Birmingham, AL, 35294, USA. lwadiche@uab.edu.ORCID 0000-0001-7367-5998
Jacques I WadicheDepartment of Neurobiology, University of Alabama at Birmingham, Birmingham, AL, 35294, USA. jwadiche@uab.edu.ORCID 0000-0001-8180-2061
University of Alabama at Birmingham · USHoward Hughes Medical Institute · US

Funding

AMPAR Function in Synaptic and Extrasynaptic MembranesR01NS113948 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WADICHE, JACQUES · 2019 to 2023
$2.1M
Inhibitory Neural Circuits in Dentate FunctionR01NS105438 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI OVERSTREET-WADICHE, LINDA · 2018 to 2022
$2.1M
Cocaine Modulation of Synapses onto Dopamine NeuronsR21DA051693 · NIDA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WADICHE, JACQUES · 2020 to 2021
$422k
Subcellular Localization of Glutamate Spillover on to Inhibitory Interneurons in the Cerebellar CortexF32NS110154 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI PENNOCK, REAGAN · 2018 to 2021
$155k
ELEVATED LEVELS OF GLUTAMATE AT CEREBELLAR SYNAPSESF32NS011095 · NINDS · OREGON HEALTH AND SCIENCE UNIVERSITY · PI WADICHE, JACQUES · 2000 to 2001
$80k
NIDA NIH HHS R21 DA051693NINDS NIH HHS F32 NS011095NINDS NIH HHS F32 NS110154NINDS NIH HHS R01 NS105438NINDS NIH HHS R01 NS113948
6 · The paper itself

Abstract

Precise alignment of pre- and postsynaptic elements optimizes the activation of glutamate receptors at excitatory synapses. Nonetheless, glutamate that diffuses out of the synaptic cleft can have actions at distant receptors, a mode of transmission called spillover. To uncover the extrasynaptic actions of glutamate, we localized AMPA receptors (AMPARs) mediating spillover transmission between climbing fibers and molecular layer interneurons in the cerebellar cortex. We found that climbing fiber spillover generates calcium transients mediated by Ca

Indexed as

Receptors, AMPASynaptic TransmissionCalciumGlutamic AcidInterneuronsSynapsesCalciumGlutamic AcidReceptors, AMPA

Identifiers

PMID37253743
PMCPMC10229553
OpenAlexW4378783246

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.