Evidence map›Paper›PMID 37253682›Full record

ArticleMusculoskeletal care2023

Sitting may increase risk for radiographic incidence and progression of knee osteoarthritis over 2 years: Data from a large cohort study.

Dana Voinier, Tuhina Neogi, Hiral Master, Louise M Thoma, Meredith Brunette, Jason Jakiela, Joshua J Stefanik, Daniel K White

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Musculoskeletal care, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Dana VoinierDepartment of Physical Therapy, University of Delaware, Newark, Delaware, USA.ORCID 0000-0001-5141-5212
Tuhina NeogiDepartment of Medicine, Section of Rheumatology, Boston University School of Medicine, Boston, Massachusetts, USA.
Hiral MasterVanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Louise M ThomaDivision of Physical Therapy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Meredith BrunetteEvidation Health Inc, San Mateo, California, USA.ORCID 0000-0002-3745-0772
Jason JakielaDepartment of Physical Therapy, University of Delaware, Newark, Delaware, USA.
Joshua J StefanikDepartment of Physical Therapy, Movement and Rehabilitation Sciences, Northeastern University, Boston, Massachusetts, USA.
Daniel K WhiteDepartment of Physical Therapy, University of Delaware, Newark, Delaware, USA.ORCID 0000-0003-3792-4621

Funding

Research and Evaluation Support Core Unit (RESCU Core)P30AR072571 · NIAMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI TUHINA NEOGI · 2019 to 2026
$6.9M
PT/PHD Predoctoral Training Program Diversity SupplementT32HD007490 · NICHD · UNIVERSITY OF DELAWARE · PI DARCY S. REISMAN · 1996 to 2026
$3.7M
The Role of Urate in Knee Osteoarthritis-Related Inflammation, Pathology and PainK24AR070892 · NIAMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI TUHINA NEOGI · 2017 to 2026
$1.1M
NIAMS NIH HHS K24 AR070892NIAMS NIH HHS P30 AR072571NICHD NIH HHS T32 HD007490NIH HHS
6 · The paper itself

Abstract

objectivesTo examine the association of leisure-time sitting with radiographic incidence and progression of knee osteoarthritis (OA) over 2 years, and to determine whether worktime sitting modifies this association.

methodsWe included adults with or at high risk for knee OA who enroled in the Osteoarthritis Initiative (OAI). Participants reported leisure-time sitting (≤4 vs. >4 h/day) and worktime sitting (frequent vs. infrequent) at enrolment, and had bilateral knee radiographs at enrolment and 2 years later. Our outcome, radiographic knee OA incidence/progression (yes/no), was defined as any increase in Kellgren-Lawrence grade over 2 years. We examined the association of leisure-time sitting (≤4 vs. >4 h/day) with risk of radiographic knee OA incidence/progression using binary linear regression, adjusting for potential confounders. We stratified by worktime sitting (frequent vs. infrequent) and repeated our analysis.

resultsWe included 4254 adults (mean age 61 years; 58% women; mean body mass index 29 kg/m

conclusionsHigher leisure-time sitting (>4 h/day) may be associated with greater risk for radiographic knee OA incidence/progression over 2 years. Furthermore, this association was intensified among adults who also reported frequent worktime sitting.

Indexed as

Osteoarthritis, KneeAdultCohort StudiesDisease ProgressionFemaleHumansIncidenceKnee JointMaleMiddle AgedRadiographyRisk Factorsarthritis

Identifiers

PMID37253682
PMCPMC10687316

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.