Evidence map›Paper›PMID 37253596›Full record

ReviewAnnual review of genomics and human genetics2023

Federated Analysis for Privacy-Preserving Data Sharing: A Technical and Legal Primer.

James Casaletto, Alexander Bernier, Robyn McDougall, Melissa S Cline

Abstract readReview
In one paragraph

Review in Annual review of genomics and human genetics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Review
  16. Review
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

James CasalettoGenomics Institute, University of California, Santa Cruz, California, USA; email: jcasalet@ucsc.edu, mcline@ucsc.edu.
Alexander BernierCentre of Genomics and Policy, Faculty of Medicine and Health Sciences, McGill University, Montreal, Quebec, Canada; email: alexander.bernier@mail.mcgill.ca, robyn.mcdougall@mail.mcgill.ca.
Robyn McDougallCentre of Genomics and Policy, Faculty of Medicine and Health Sciences, McGill University, Montreal, Quebec, Canada; email: alexander.bernier@mail.mcgill.ca, robyn.mcdougall@mail.mcgill.ca.
Melissa S ClineGenomics Institute, University of California, Santa Cruz, California, USA; email: jcasalet@ucsc.edu, mcline@ucsc.edu.

Funding

Training SubprojectU54HG007990 · NHGRI · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI HAUSSLER, DAVID H, PATTERSON, DAVID · 2014 to 2018
$14.8M
Enabling Comparative PangenomicsR01HG010485 · NHGRI · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI HAUSSLER, DAVID H, MARTIN, FERGAL JAMES · 2020 to 2023
$2.6M
Unbiased analysis of genomic correlates of gene expression in health and diseaseU01HL137183 · NHLBI · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI HAUSSLER, DAVID H · 2017 to 2019
$1.8M
Federated Analysis in Cancer Genomics: Surveying the Social, Ethical, and Regulatory LandscapeU01CA242954 · NCI · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI CLINE, MELISSA SUZANNE · 2019 to 2021
$1.5M
NCI NIH HHS U01 CA242954NHGRI NIH HHS R01 HG010485NHGRI NIH HHS U54 HG007990NHLBI NIH HHS U01 HL137183
6 · The paper itself

Abstract

Continued advances in precision medicine rely on the widespread sharing of data that relate human genetic variation to disease. However, data sharing is severely limited by legal, regulatory, and ethical restrictions that safeguard patient privacy. Federated analysis addresses this problem by transferring the code to the data-providing the technical and legal capability to analyze the data within their secure home environment rather than transferring the data to another institution for analysis. This allows researchers to gain new insights from data that cannot be moved, while respecting patient privacy and the data stewards' legal obligations. Because federated analysis is a technical solution to the legal challenges inherent in data sharing, the technology and policy implications must be evaluated together. Here, we summarize the technical approaches to federated analysis and provide a legal analysis of their policy implications.

Indexed as

FenbendazolePrivacyHealth FacilitiesHumansInformation DisseminationPolicyFenbendazolefederated analysisfederationGDPRgenomicsprivacy protection

Identifiers

PMID37253596
PMCPMC10846631

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.