Evidence map›Paper›PMID 37253412›Full record

ArticleThe Journal of nutrition2023

Placental Erythroferrone and Erythropoietin mRNA Expression is not Associated with Maternal or Neonatal Iron Status in Adolescents Carrying Singletons and Adult Women Carrying Multiples.

Katherine M Delaney, Alexa Barad, Luisa F Castillo, Chloe M Hasund, Ronnie Guillet, Eva K Pressman, Philip J Katzman, Tomas Ganz, Elizabeta Nemeth, Kimberly O O'Brien

2 registry-linked trialsOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of nutrition, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01019902 completednot on this map

Impact of Maternal Iron Status on Neonatal Iron Status and Auditory Brainstem Response in the Newborn

TypeobservationalSponsorCornell UniversityRan2008 to 2013Enrolled144ConditionsAnemia
NCT01582802 unknown statusnot on this map

Determinants of Neonatal Iron Homeostasis in Women Carrying Multiples

TypeobservationalSponsorCornell UniversityRan2011 to 2023Enrolled350ConditionsAnemia
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Katherine M DelaneyDivision of Nutritional Sciences, Cornell University, Ithaca, NY, United States.
Alexa BaradDivision of Nutritional Sciences, Cornell University, Ithaca, NY, United States.
Luisa F CastilloDivision of Nutritional Sciences, Cornell University, Ithaca, NY, United States.
Chloe M HasundDivision of Nutritional Sciences, Cornell University, Ithaca, NY, United States.
Ronnie GuilletDepartment of Pediatrics Division of Neonatology, University of Rochester School of Medicine, Rochester, NY, United States.
Eva K PressmanDepartment of Obstetrics and Gynecology, University of Rochester School of Medicine, Rochester, NY, United States.
Philip J KatzmanDepartment of Pathology and Clinical Laboratory Medicine, University of Rochester School of Medicine, Rochester, NY, United States.
Tomas GanzDavid Geffen School of Medicine, Center for Iron Disorders, University of California Los Angeles, Los Angeles, CA, United States.
Elizabeta NemethDavid Geffen School of Medicine, Center for Iron Disorders, University of California Los Angeles, Los Angeles, CA, United States.
Kimberly O O'BrienDivision of Nutritional Sciences, Cornell University, Ithaca, NY, United States. Electronic address: koo4@cornell.edu.
Cornell University · USUniversity of Rochester · USUniversity of California, Los Angeles · US

Funding

NUTRITION TRAININGT32DK007158 · NIDDK · CORNELL UNIVERSITY ITHACA · PI PATRICIA A CASSANO, Julia L. Finkelstein · 1986 to 2026
$7.4M
Erythroferrone and Its Impact on Maternal and Neonatal Iron HomeostasisR21HD098864 · NICHD · CORNELL UNIVERSITY · PI NEMETH, ELIZABETA, O'BRIEN, KIMBERLY O · 2019 to 2020
$445k
NICHD NIH HHS R21 HD098864NIDDK NIH HHS T32 DK007158
6 · The paper itself

Abstract

backgroundThe iron regulatory hormones erythroferrone (ERFE), erythropoietin (EPO), and hepcidin, and the cargo receptor nuclear receptor coactivator 4 (NCOA4) are expressed in the placenta. However, determinants of placental expression of these proteins and their associations with maternal or neonatal iron status are unknown.

objectivesTo characterize expression of placental ERFE, EPO, and NCOA4 mRNA in placentae from newborns at increased risk of iron deficiency and to evaluate these in relation to maternal and neonatal iron status and regulatory hormones.

methodsPlacentae were collected from 114 neonates born to adolescents carrying singletons (14-18 y) and 110 neonates born to 54 adults (20-46 y) carrying multiples. Placental EPO, ERFE, and NCOA4 mRNA expression were measured by RT-qPCR and compared with maternal and neonatal iron status indicators (SF, sTfR, total body iron, serum iron) and hormones.

resultsPlacental ERFE, EPO, and NCOA4 mRNA were detected in all placentae delivered between 25 and 42 wk of gestation. Relationships between placental ERFE and EPO differed by cohort. In the multiples cohort, placental EPO and ERFE were positively correlated (P = 0.004), but only a positive trend (P = 0.08) was evident in the adolescents. Placental EPO and ERFE were not associated with maternal or neonatal iron status markers or hormones in either cohort. Placental NCOA4 was not associated with placental EPO or ERFE in either cohort but was negatively associated with maternal SF (P = 0.03) in the multiples cohort and positively associated with neonatal sTfR (P = 0.009) in the adolescents.

conclusionsThe human placenta expresses ERFE, EPO, and NCOA4 mRNA as early as 25 wk of gestation. Placental expression of ERFE and EPO transcripts was not associated with maternal or neonatal iron status. Greater placental NCOA4 transcript expression was evident in women and newborns with poor iron status (lower SF and higher sTfR, respectively). Further research is needed to characterize the roles of these proteins in the human placenta. TRIAL REGISTRATION NUMBER: These clinical trials were registered at clinicaltrials.gov as NCT01019902 (https://clinicaltrials.gov/ct2/show/NCT01019902) and NCT01582802 (https://clinicaltrials.gov/ct2/show/NCT01582802).

Indexed as

ErythropoietinIronAdolescentAdultFemaleHepcidinsHormonesHumansInfant, NewbornPeptide HormonesPlacentaPregnancyRNA, MessengerEPO protein, humanErfe protein, humanErythropoietinHepcidinsHormonesIronPeptide HormonesRNA, Messengeranemiairon deficiencynuclear receptor coactivator 4placentaplacental mRNA

Identifiers

PMID37253412
PMCPMC10375499
OpenAlexW4378571826

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.