ArticleProceedings of the National Academy of Sciences of the United States of America2023
Tuft cells mediate commensal remodeling of the small intestinal antimicrobial landscape.
Open access · greenAbstract read
In one paragraph
Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
6.3field-weighted citation impact, top 2% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 39 citations in OpenAlex.
- Dietary vitamin A restricts intestinal tuft cell differentiation.Cell reports · 2026Article
- Soybean-Derived Soluble Fiber Enhances Antimicrobial Proteins in the Mouse Small Intestine via a Tuft Cell-Group 2 Innate Lymphoid Cell Axis.Journal of agricultural and food chemistry · 2026Article
- Article
- Gastrointestinal tuft cells: Recent insights and next questions.Science immunology · 2026Review
- Integrative host transcriptomic and mucosal microbiome profiling reveals region-specific host-microbiome associations across the human intestine.bioRxiv : the preprint server for biology · 2026Article
- Cytokine networks in Paneth cell regulation.Mucosal immunology · 2026Review
- Article
- Tuft cells shape airway remodeling by eliciting OXGR1- and SOX9-dependent stem cell programs.Nature communications · 2026Article
- Regulation of allergies across the body by microbial metabolites.Experimental & molecular medicine · 2026Review
- Gut microbiota and parasite dynamics in an Amazonian community undergoing urbanization in Colombia.mSphere · 2026Article
- Intestinal epithelial cells in health and disease.Tissue barriers · 2026Review
- Tuft Cells in the Gut Limit Cognitive Disorders by Regulating Gut Homeostasis.Cellular and molecular gastroenterology and hepatology · 2026Article
- Renshen-Baidu-San restores epithelial-immune crosstalk and drives type 2 immune repair in ulcerative colitis: an integrated multi-omics study.Frontiers in immunology · 2026Article
- The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases.FEBS letters · 2025Review
- Microbiota-mediated mechanisms of mucosal immunity across the lifespan.Nature immunology · 2025Review
- DOCK8 in T cells promotes Th17 and Treg cell functionality to restrain mucosal mast cells and limit susceptibility to oral anaphylaxis.Immunity · 2025Article
- Tuft cell IL-17RB restrains IL-25 bioavailability and reveals context-dependent ILC2 hypoproliferation.Nature immunology · 2025Article
- Type 2 immunity in allergic diseases.Cellular & molecular immunology · 2025Review
- Delving the depths of 'terra incognita' in the human intestine - the small intestinal microbiota.Nature reviews. Gastroenterology & hepatology · 2025Review
- The role of the tuft cell-interleukin-25 axis in the pathogenesis of inflammatory bowel disease.Frontiers in immunology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 2 institutions in 1 country.
Connie FungDepartment of Pathology, Stanford University School of Medicine, Stanford, CA 94305.ORCID 0000-0003-1693-5719
Lisa M FraserDivision of Gastroenterology, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI 53226.
Gabriel M BarrónDepartment of Pathology, Stanford University School of Medicine, Stanford, CA 94305.ORCID 0000-0002-1442-5072
Matthew B GologorskyDepartment of Pathology, Stanford University School of Medicine, Stanford, CA 94305.ORCID 0000-0002-2968-1159
Samantha N AtkinsonDepartment of Microbiology and Immunology, Center for Microbiome Research, Medical College of Wisconsin, Milwaukee, WI 53226.
Elias R GerrickDepartment of Pathology, Stanford University School of Medicine, Stanford, CA 94305.
Michael HaywardDivision of Gastroenterology, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI 53226.
Jennifer ZiegelbauerDepartment of Microbiology and Immunology, Center for Microbiome Research, Medical College of Wisconsin, Milwaukee, WI 53226.
Jessica A LiDepartment of Pathology, Stanford University School of Medicine, Stanford, CA 94305.ORCID 0000-0001-7915-8908
Katherine F NicoDepartment of Pathology, Stanford University School of Medicine, Stanford, CA 94305.
Miles D W TynerDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305.
Leila B DeSchepperDepartment of Pathology, Stanford University School of Medicine, Stanford, CA 94305.
Amy PanDepartment of Microbiology and Immunology, Center for Microbiome Research, Medical College of Wisconsin, Milwaukee, WI 53226.
Nita H SalzmanDivision of Gastroenterology, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI 53226.ORCID 0000-0003-0939-6139
Michael R HowittDepartment of Pathology, Stanford University School of Medicine, Stanford, CA 94305.ORCID 0000-0002-3643-2468
Stanford University · USMedical College of Wisconsin · US
Funding
Intestinal Enterococcal Dynamics: Modeling Host-Commensal and Host-Pathogen InteractionsR35GM122503 · NIGMS · MEDICAL COLLEGE OF WISCONSIN · PI SALZMAN, NITA H · 2017 to 2021
$2.7MStanford ChEM-H Chemistry/Biology Interface Predoctoral Training ProgramT32GM139791 · NIGMS · STANFORD UNIVERSITY · PI Carolyn Bertozzi, Christine Jacobs-Wagner · 2021 to 2026
$2.4MImpact of symbiotic protists on intestinal T cell homeostasis and inflammation.R01DK128292 · NIDDK · STANFORD UNIVERSITY · PI HOWITT, MICHAEL R · 2021 to 2025
$2.3MUltra high throughput sequencer for sustaining and enhancing multi-scale genomic studiesS10OD025212 · OD · STANFORD UNIVERSITY · PI SNYDER, MICHAEL P. · 2018 to 2018
$600kComputer ClusterS10OD021763 · OD · STANFORD UNIVERSITY · PI JI, HANLEE P · 2016 to 2016
$481kTuft cell regulation of Peyers patch composition and organizationR21AI171222 · NIAID · STANFORD UNIVERSITY · PI HOWITT, MICHAEL R · 2022 to 2023
$438kOneView 4kX4k sCMOS camera for transmission electron microscopy applicationsS10OD028536 · OD · STANFORD UNIVERSITY · PI MULHOLLAND, JONATHAN W · 2020 to 2020
$195kNIAID NIH HHS R21 AI171222NIDDK NIH HHS R01 DK128292NIGMS NIH HHS R35 GM122503NIGMS NIH HHS T32 GM139791NIH HHS S10 OD021763NIH HHS S10 OD025212NIH HHS S10 OD028536
Abstract
Succinate produced by the commensal protist
Indexed as
Anti-Infective AgentsIntestinal MucosaAnimalsIntestinesIntestine, SmallMiceSuccinic AcidAnti-Infective AgentsSuccinic Acidantimicrobial peptidesPaneth cellsuccinatetuft celltype 2 immunity
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.