ArticleProceedings of the National Academy of Sciences of the United States of America2023
Local response and emerging nonlinear elastic length scale in biopolymer matrices.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Multiscale Architecture and Mechanics of the Cell Nucleus: Implications for Disease, Bioengineering and Nanomedicine.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Matrix influence of collagen: fibrin interpenetrating hydrogels on microvascular networks and osteogenesis.Biomaterials advances · 2026Article
- Optical tweezers microrheology maps micro-mechanics of complex systems.Trends in biochemical sciences · 2024Article
- Microinterfaces in biopolymer-based bicontinuous hydrogels guide rapid 3D cell migration.Nature communications · 2024Article
- Unexpected softening of a fibrous matrix by contracting inclusions.Acta biomaterialia · 2024Article
- Editorial: Mechanobiology of organoid systems.Frontiers in cell and developmental biology · 2024Article
- Local response and emerging nonlinear elastic length scale in biopolymer matrices.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Nonlinear stiffening is a ubiquitous property of major types of biopolymers that make up the extracellular matrices (ECM) including collagen, fibrin, and basement membrane. Within the ECM, many types of cells such as fibroblasts and cancer cells have a spindle-like shape that acts like two equal and opposite force monopoles, which anisotropically stretch their surroundings and locally stiffen the matrix. Here, we first use optical tweezers to study the nonlinear force-displacement response to localized monopole forces. We then propose an effective-probe scaling argument that a local point force application can induce a stiffened region in the matrix, which can be characterized by a nonlinear length scale
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.