Evidence map›Paper›PMID 37252954›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

Peptidoglycan deacetylation controls type IV secretion and the intracellular survival of the bacterial pathogen

David Boamah, Michael C Gilmore, Sarah Bourget, Anushka Ghosh, Mohammad J Hossain, Joseph P Vogel, Felipe Cava, Tamara J O'Connor

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

  1. ACS infectious diseases · 2026
    Article
  2. mBio · 2025
    Article
  3. Article
  4. Article
  5. Antibacterial carbon dots.Materials today. Bio · 2025
    Review
  6. Journal of bacteriology · 2024
    Review
  7. Review
  8. Membrane association and polar localization of theProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  9. Bacterial growth dynamics in a rhythmic symbiosis.Molecular biology of the cell · 2024
    Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

David BoamahDepartment of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Michael C GilmoreDepartment of Molecular Biology, Laboratory for Molecular Infection Medicine Sweden, Umeå Centre for Microbial Research, Umeå University, Umeå 90187, Sweden.ORCID 0000-0002-6848-5134
Sarah BourgetDepartment of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Anushka GhoshDepartment of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205.ORCID 0000-0001-6699-7737
Mohammad J HossainDepartment of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Joseph P VogelDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110.
Felipe CavaDepartment of Molecular Biology, Laboratory for Molecular Infection Medicine Sweden, Umeå Centre for Microbial Research, Umeå University, Umeå 90187, Sweden.ORCID 0000-0001-5995-718X
Tamara J O'ConnorDepartment of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Johns Hopkins University · USUmeå University · SEWashington University in St. Louis · US

Funding

Identifying genes essential for Legionella persistence and transmissionR21AI119580 · NIAID · JOHNS HOPKINS UNIVERSITY · PI O'CONNOR, TAMARA · 2015 to 2016
$446k
NIAID NIH HHS R21 AI119580
6 · The paper itself

Abstract

Peptidoglycan is a critical component of the bacteria cell envelope. Remodeling of the peptidoglycan is required for numerous essential cellular processes and has been linked to bacterial pathogenesis. Peptidoglycan deacetylases that remove the acetyl group of the

Indexed as

LegionellaLegionella pneumophilaLegionnaires' DiseaseBacterial ProteinsHumansLysosomesPeptidoglycanVacuolesBacterial ProteinsPeptidoglycanDotKLegionellapeptidoglycanpolysaccharide deacetylasetype IV secretion system

Identifiers

PMID37252954
PMCPMC10266036
OpenAlexW4378782620

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.