Evidence map›Paper›PMID 37252938›Full record

ArticleACS nano2023

STAMP-Based Digital CRISPR-Cas13a for Amplification-Free Quantification of HIV-1 Plasma Viral Loads.

Reza Nouri, Yuqian Jiang, Anthony J Politza, Tianyi Liu, Wallace H Greene, Yusheng Zhu, Jonathan J Nunez, Xiaojun Lian, Weihua Guan

Abstract read
In one paragraph

Article in ACS nano, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Review
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  14. Palm-Sized Lab-In-A-Magnetofluidic Tube Platform for Rapid and Sensitive Virus Detection.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  15. The Current Situation and Development Prospect of Whole-Genome Screening.International journal of molecular sciences · 2024
    Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. HIV infection detection using CRISPR/Cas systems: Present and future prospects.Computational and structural biotechnology journal · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Reza NouriDepartment of Electrical Engineering, Pennsylvania State University, University Park, Pennsylvania 16802, United States.
Yuqian JiangDepartment of Biomedical Engineering, Pennsylvania State University, University Park, Pennsylvania 16802, United States.
Anthony J PolitzaDepartment of Biomedical Engineering, Pennsylvania State University, University Park, Pennsylvania 16802, United States.
Tianyi LiuDepartment of Electrical Engineering, Pennsylvania State University, University Park, Pennsylvania 16802, United States.
Wallace H GreeneDepartment of Pathology, Penn State College of Medicine, Hershey, Pennsylvania 17033, United States.
Yusheng ZhuDepartment of Pathology, Penn State College of Medicine, Hershey, Pennsylvania 17033, United States.
Jonathan J NunezDepartment of Medicine, Penn State College of Medicine and Milton S. Hershey Medical Center, Hershey, Pennsylvania 17033, United States.
Xiaojun LianDepartment of Biomedical Engineering, Pennsylvania State University, University Park, Pennsylvania 16802, United States.
Weihua GuanDepartment of Electrical Engineering, Pennsylvania State University, University Park, Pennsylvania 16802, United States.ORCID 0000-0002-8435-9672

Funding

Home Fingerprick Blood-Based HIV Self-Test For Quantitative Monitoring Of Viral ReboundR33AI147419 · NIAID · PENNSYLVANIA STATE UNIVERSITY, THE · PI GUAN, WEIHUA · 2023 to 2024
$1.3M
Home Fingerprick Blood-Based HIV Self-Test For Quantitative Monitoring Of Viral ReboundR61AI147419 · NIAID · PENNSYLVANIA STATE UNIVERSITY, THE · PI GUAN, WEIHUA · 2020 to 2022
$1.0M
NIAID NIH HHS R33 AI147419NIAID NIH HHS R61 AI147419
6 · The paper itself

Abstract

Quantification of HIV RNA in plasma is critical for identifying the disease progression and monitoring the effectiveness of antiretroviral therapy. While RT-qPCR has been the gold standard for HIV viral load quantification, digital assays could provide an alternative calibration-free absolute quantification method. Here, we reported a

Indexed as

HIV-1HIV InfectionsHumansRNA, ViralSensitivity and SpecificityViral LoadRNA, ViralCas 13aCRISPRdigitalHIV-1quantificationviral load

Identifiers

PMID37252938
PMCPMC11240847

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.