ArticleIEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society2023
Comparison of EEG Source Localization Using Simplified and Anatomically Accurate Head Models in Younger and Older Adults.
Article in IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 27 citations in OpenAlex.
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- Human brain imaging with high-density electroencephalography: Techniques and applications.The Journal of physiology · 2026Review
- Age differences in electrocortical dynamics during uneven terrain walking.bioRxiv : the preprint server for biology · 2025Article
- Affective information modulates slow-wave- and arousal-like responses during NREM sleep.Communications biology · 2025Article
- Gait speed-related changes in electrocortical activity in younger and older adults.Journal of neurophysiology · 2025Article
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- Mapping Brain-Wide Neural Activity of Murine Attentional Processing in the Five-Choice Serial Reaction Time Task.Neuroscience bulletin · 2025Article
- Age differences in electrocortical dynamics during uneven terrain walking.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Editorial: Multimodal approaches to investigating neural dynamics in cognition and related clinical conditions: integrating EEG, MEG, and fMRI data.Frontiers in systems neuroscience · 2025Article
- Scalp electrode placement accuracy for the canine electroencephalography array.Frontiers in veterinary science · 2025Article
- Mobile neuroimaging: What we have learned about the neural control of human walking, with an emphasis on EEG-based research.Neuroscience and biobehavioral reviews · 2024Review
- Electrical brain activity during human walking with parametric variations in terrain unevenness and walking speed.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Investigating the effect of template head models on Event-Related Potential source localization: a simulation and real-data study.Frontiers in neuroscience · 2024Article
- Visual Occlusions Result in Phase Synchrony Within Multiple Brain Regions Involved in Sensory Processing and Balance Control.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2023Article
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Authors and funding
12 authors at 2 institutions in 2 countries.
Funding
Abstract
Accuracy of electroencephalography (EEG) source localization relies on the volume conduction head model. A previous analysis of young adults has shown that simplified head models have larger source localization errors when compared with head models based on magnetic resonance images (MRIs). As obtaining individual MRIs may not always be feasible, researchers often use generic head models based on template MRIs. It is unclear how much error would be introduced using template MRI head models in older adults that likely have differences in brain structure compared to young adults. The primary goal of this study was to determine the error caused by using simplified head models without individual-specific MRIs in both younger and older adults. We collected high-density EEG during uneven terrain walking and motor imagery for 15 younger (22±3 years) and 21 older adults (74±5 years) and obtained [Formula: see text]-weighted MRI for each individual. We performed equivalent dipole fitting after independent component analysis to obtain brain source locations using four forward modeling pipelines with increasing complexity. These pipelines included: 1) a generic head model with template electrode positions or 2) digitized electrode positions, 3) individual-specific head models with digitized electrode positions using simplified tissue segmentation, or 4) anatomically accurate segmentation. We found that when compared to the anatomically accurate individual-specific head models, performing dipole fitting with generic head models led to similar source localization discrepancies (up to 2 cm) for younger and older adults. Co-registering digitized electrode locations to the generic head models reduced source localization discrepancies by ∼ 6 mm. Additionally, we found that source depths generally increased with skull conductivity for the representative young adult but not as much for the older adult. Our results can help inform a more accurate interpretation of brain areas in EEG studies when individual MRIs are unavailable.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.