Evidence map›Paper›PMID 37252680›Full record

ArticleJournal of immunology research2023

The Underlying Mechanism of Duanteng Yimu Decoction in Inhibiting Synovial Hyperplasia in Rheumatoid Arthritis.

Wei Feng, Xiao-Qin Zhong, Xue-Xia Zheng, Qing-Ping Liu, Min-Ying Liu, Xiao-Bao Liu, Chang-Song Lin, Qiang Xu

Open access · goldAbstract read
In one paragraph

Article in Journal of immunology research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Wei Feng *The First Clinical Medicine School, Guangzhou University of Chinese Medicine, Guangzhou 510405, China.ORCID https://orcid.org/0000-0003-0025-8100
Xiao-Qin Zhong *The First Clinical Medicine School, Guangzhou University of Chinese Medicine, Guangzhou 510405, China.
Xue-Xia Zheng *The First Clinical Medicine School, Guangzhou University of Chinese Medicine, Guangzhou 510405, China.
Qing-Ping LiuThe First Clinical Medicine School, Guangzhou University of Chinese Medicine, Guangzhou 510405, China.
Min-Ying LiuThe First Clinical Medicine School, Guangzhou University of Chinese Medicine, Guangzhou 510405, China.
Xiao-Bao LiuThe First Clinical Medicine School, Guangzhou University of Chinese Medicine, Guangzhou 510405, China.
Chang-Song LinThe First Clinical Medicine School, Guangzhou University of Chinese Medicine, Guangzhou 510405, China.ORCID https://orcid.org/0009-0000-6331-8997
Qiang XuThe First Clinical Medicine School, Guangzhou University of Chinese Medicine, Guangzhou 510405, China.ORCID https://orcid.org/0000-0001-8510-6127
Guangzhou University of Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dysregulation of microRNAs (miRNAs) is associated with the pathogenesis of rheumatoid arthritis (RA). Our previous studies confirmed that Duanteng Yimu decoction (DTYMT) effectively inhibits RA fibroblast-like synoviocyte (FLS) proliferation. In this study, we investigated the influence of DTYMT on miR-221 in RA individuals. Hematoxylin-eosin (HE) staining was performed to assess histopathological alterations in collagen-induced arthritis (CIA) mice. The expression of miR-221-3p and TLR4 in PBMC, FLS, and cartilage was measured by RT-qPCR. In the in vitro experiments, DTYMT-containing serum was incubated with FLS-transfected miR-221 mimic or inhibitor. CCK-8 was performed to determine FLS proliferation, and the secretion of IL-1

Indexed as

Arthritis, ExperimentalArthritis, RheumatoidMicroRNAsSynoviocytesAnimalsCell ProliferationCells, CulturedFibroblastsHyperplasiaInterleukin-18Interleukin-6Leukocytes, MononuclearMiceMyeloid Differentiation Factor 88Synovial MembraneToll-Like Receptor 4Interleukin-18Interleukin-6MicroRNAsMyeloid Differentiation Factor 88Toll-Like Receptor 4Tumor Necrosis Factor-alpha

Identifiers

PMID37252680
PMCPMC10225272
OpenAlexW4377197032

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.