Evidence map›Paper›PMID 37252677›Full record

ArticleClinical parkinsonism & related disorders2023

Gait and balance in apolipoprotein Ɛ4 allele carriers in older adults and Parkinson's disease.

Rosie Morris, Douglas N Martini, Valerie E Kelly, Katrijn Smulders, Katrina Ramsey, Amie Hiller, Kathryn A Chung, Shu-Ching Hu, Cyrus P Zabetian, Kathleen L Poston and 7 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical parkinsonism & related disorders, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01720810 (Pacific Northwest Udall Center), which is not on this map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01720810 unknown statusnot on this map

Pacific Northwest Udall Center (PANUC) Clinical Core

TypeobservationalSponsorUniversity of WashingtonRan2010 to 2025Enrolled2,000ConditionsParkinson Disease, Cognitive Impairment
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Apolipoprotein E Gene in α-Synucleinopathies: A Narrative Review.International journal of molecular sciences · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 6 institutions in 3 countries.

Rosie MorrisDepartment of Neurology, Oregon Health and Science University, Portland, OR, USA.
Douglas N MartiniDepartment of Neurology, Oregon Health and Science University, Portland, OR, USA.
Valerie E KellyDepartment of Rehabilitation Medicine, University of Washington School of Medicine, Seattle, WA, USA.
Katrijn SmuldersSint Maartenskliniek Research Department, Nijmegen, the Netherlands.
Katrina RamseySchool of Public Health, Oregon Health and Science University, Portland, OR, USA.
Amie HillerDepartment of Neurology, Oregon Health and Science University, Portland, OR, USA.
Kathryn A ChungDepartment of Neurology, Oregon Health and Science University, Portland, OR, USA.
Shu-Ching HuSint Maartenskliniek Research Department, Nijmegen, the Netherlands.
Cyrus P ZabetianSint Maartenskliniek Research Department, Nijmegen, the Netherlands.
Kathleen L PostonDepartment of Neurology, University of Washington School of Medicine, Seattle, WA, USA.
Ignacio F MataSint Maartenskliniek Research Department, Nijmegen, the Netherlands.
Karen L EdwardsDepartment of Neurology and Neurological Sciences, Stanford School of Medicine, Palo Alto, CA, US.
Jodi LapidusSchool of Public Health, Oregon Health and Science University, Portland, OR, USA.
Brenna CholertonLerner Research Institute, Genomic Medicine, Cleveland Clinic Foundation, Cleveland, OH, USA.
Thomas J MontineLerner Research Institute, Genomic Medicine, Cleveland Clinic Foundation, Cleveland, OH, USA.
Joseph F QuinnDepartment of Neurology, Oregon Health and Science University, Portland, OR, USA.
Fay HorakDepartment of Neurology, Oregon Health and Science University, Portland, OR, USA.
Oregon Health & Science University · USSint Maartenskliniek · NLCleveland Clinic · USUniversity of Washington · USStanford Medicine · USVA Puget Sound Health Care System · US

Funding

Oregon Clinical and Translational Research Institute - The National COVID Cohort Collaborative (N3C)UL1TR002369 · NCATS · OREGON HEALTH & SCIENCE UNIVERSITY · PI Cynthia D Morris, Christopher G. Slatore · 2017 to 2026
$78.4M
Udall Center Director's meeting poster awardP50NS062684 · NINDS · UNIVERSITY OF WASHINGTON · PI MONTINE, THOMAS J · 2009 to 2020
$18.3M
Genetic Movement Disorders: Etiologies and PathogenesesI01CX001702 · VA · VA PUGET SOUND HEALTHCARE SYSTEM · PI CYRUS P ZABETIAN · 2018 to 2026
–
CSRD VA I01 CX001702NCATS NIH HHS UL1 TR002369NINDS NIH HHS P50 NS062684
6 · The paper itself

Abstract

Background: Gait and balance impairments are among the most troublesome and heterogeneous in Parkinson's disease (PD). This heterogeneity may, in part, reflect genetic variation. The apolipoprotein E ( Methods: 334 people with PD (81 Results: Gait and balance were worse in people with PD compared to OA. However, there were no differences between Conclusions: Although we found expected impairments in gait and balance in PD compared to OA, gait and balance characteristics did not differ between

Indexed as

APOEBalanceGaitOlder adultsParkinson’s disease

Identifiers

PMID37252677
PMCPMC10209874
OpenAlexW4376874626

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.