ArticleInternational journal of dentistry2023
Physiological Gingival Melanin Hyperpigmentation Treatment with Injectable Vitamin C and Scalpel Technique: A Randomised Controlled Clinical Trial.
Article in International journal of dentistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- Meta-analysis of randomized controlled trials: efficacy of vitamin C mesotherapy for gingival hyperpigmentation in adults.BMC oral health · 2025Pooled it
- Therapeutic Impact of Ascorbic Acid on Oral and Periodontal Tissues: A Systematic Literature Review.Medicina (Kaunas, Lithuania) · 2024Pooled it
- Effectiveness of omega-3 poly unsaturated fatty acids on the treatment of gingival hyperpigmentation: a randomized controlled clinical trial.BMC oral health · 2026Trial
- Gingival depigmentation by conservative injectable vitamin C in comparison with scalpel surgery: a randomized controlled split-mouth clinical trial.BMC research notes · 2025Trial
- Ceramic soft tissue trimming bur gingival depigmentation: clinical performance and patient experience. A split mouth randomized controlled trial.BMC oral health · 2024Trial
- Vitamin C-Based Gingival Depigmentation Versus Surgical Depigmentation: A Randomized Clinical Trial.TheScientificWorldJournal · 2024Trial
- Vitamin C mesotherapy versus diode laser for the esthetic management of physiologic gingival hyperpigmentation: a randomized clinical trial.BMC oral health · 2023Trial
- How Effective Is Vitamin C for Gingival Depigmentation? A Scoping Review.Clinical and experimental dental research · 2026Article
- Effectiveness of Vitamin C for Gingival Depigmentation: A Systematic Review.International journal of dentistry · 2026Article
- Article
- Comparison of Various Minimally Invasive Techniques for the Management of Gingival Hyperpigmentation: A Case Report.Cureus · 2024Article
- Article
- A Minimally Invasive Technique for the Management of Physiologic Gingival Melanin Hyperpigmentation: A Case Series.Cureus · 2024Article
- Efficacy of Topical Vitamin C Application on Healing After Gingival Depigmentation by Scalpel: A Case Series.Cureus · 2023Article
- Efficacy and Risks of Different Treatments for Oral Hyperpigmentation: A Systematic Review and Network Meta-Analysis.Journal of clinical medicine · 2023Review
- Effectiveness of Vitamin C in managing gingival hyperpigmentation: A systematic review and meta-analysis.Journal of Indian Society of PeriodontologyReview
- Clinical and patient-reported outcomes of microneedling with ascorbic acid versus scalpel technique for gingival depigmentation: A randomized clinical trial.Journal of oral biology and craniofacial researchArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Harmony between facial complexion and gingival health goes hand in hand. Gingival depigmentation is an aesthetic correction of hyperactive melanocytes in gingival tissues that lead to hyperpigmentation. Current study compares depigmentation, pain scores, and itching with scalpel technique and nonsurgical intramucosal Vitamin C injection. 30 individuals in the age range of 18-40 years conscious of dark gums were randomly allocated to test and control group by lottery method. Thorough Phase I therapy was performed one week before the procedure. Area and intensity of depigmentation were evaluated preoperatively and postoperatively; pain score, itching, and repigmentation percentage were the postoperative parameters. After 24 hrs, test group showed significantly lesser VAS score for pain as compared to control group. There was no statistically significant difference in preoperative area of pigmentation between the test and control group (
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.