Evidence map›Paper›PMID 37252254›Full record

ArticlePhytochemistry letters2023

What was old is new again: Phenotypic screening of a unique fungal library yields pyridoxatin, a promising lead against extensively resistant

Heather L Winter, Laura Flores-Bocanegra, Kristóf B Cank, William J Crandall, Fridah C Rotich, Madeline N Tillman, Daniel A Todd, Tyler N Graf, Huzefa A Raja, Cedric J Pearce and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Phytochemistry letters, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Heather L WinterDepartment of Chemistry and Biochemistry, The University of North Carolina at Greensboro, Greensboro, NC, USA.
Laura Flores-BocanegraDepartment of Chemistry and Biochemistry, The University of North Carolina at Greensboro, Greensboro, NC, USA.
Kristóf B CankDepartment of Chemistry and Biochemistry, The University of North Carolina at Greensboro, Greensboro, NC, USA.
William J CrandallDepartment of Chemistry and Biochemistry, The University of North Carolina at Greensboro, Greensboro, NC, USA.
Fridah C RotichDepartment of Chemistry and Biochemistry, The University of North Carolina at Greensboro, Greensboro, NC, USA.
Madeline N TillmanDepartment of Chemistry and Biochemistry, The University of North Carolina at Greensboro, Greensboro, NC, USA.
Daniel A ToddDepartment of Chemistry and Biochemistry, The University of North Carolina at Greensboro, Greensboro, NC, USA.
Tyler N GrafDepartment of Chemistry and Biochemistry, The University of North Carolina at Greensboro, Greensboro, NC, USA.
Huzefa A RajaDepartment of Chemistry and Biochemistry, The University of North Carolina at Greensboro, Greensboro, NC, USA.
Cedric J PearceMycosynthetix, Inc., Hillsborough, NC, USA.
Nicholas H OberliesDepartment of Chemistry and Biochemistry, The University of North Carolina at Greensboro, Greensboro, NC, USA.
Nadja B CechDepartment of Chemistry and Biochemistry, The University of North Carolina at Greensboro, Greensboro, NC, USA.
University of North Carolina at Greensboro · USMycosynthetix (United States) · US

Funding

Predoctoral Training: Innovative Technologies for Natural Products and Integrative Medicine ResearchT32AT008938 · NCCIH · UNIVERSITY OF NORTH CAROLINA GREENSBORO · PI Nadja B Cech, Jonathan Rodi Chekan · 2016 to 2026
$1.6M
Metabolomics for Determining Mechanism of Action of Botanical MedicinesF31AT011152 · NCCIH · UNIVERSITY OF NORTH CAROLINA GREENSBORO · PI WINTER, HEATHER · 2021 to 2022
$59k
NCCIH NIH HHS F31 AT011152NCCIH NIH HHS T32 AT008938
6 · The paper itself

Abstract

Due to the emergence of resistance, the World Health Organization considers Gram-negative pathogen

Indexed as

Acinetobacter baumanniiantibiotic resistanceGalleria mellonellapeptaibolsPyridoxatin

Identifiers

PMID37252254
PMCPMC10210987
OpenAlexW4366774903

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.