ArticleJournal of pain research2023
Pulsed Radiofrequency Decreases pERK and Affects Intracellular Ca
Article in Journal of pain research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 7 citations in OpenAlex.
- Radiofrequency Fields at 2.45 GHz Reprogram Mitochondria-Lysosome Crosstalk and Modulate the Survival/Death of Macrophages Exposed to LPS and/or the SARS-CoV-2 Spike Protein.International journal of molecular sciences · 2026Article
- Effects of Esketamine Infusion by Patient-Controlled Intravenous Analgesia in Patients With Zoster-Associated Pain: A Retrospective Study.Medical science monitor : international medical journal of experimental and clinical research · 2026Article
- The effects of pulsed radiofrequency stimulation on mitochondrial function in neurons: a mini review.Frontiers in pain research (Lausanne, Switzerland) · 2026Review
- Pulsed Radiofrequency for Lumbosacral Radicular Pain in Dogs: Description and Assessment of an Ultrasound- and Fluoroscopy-Guided Technique in a Cadaveric Model.Animals : an open access journal from MDPI · 2025Article
- Endoplasmic reticulum-mitochondria crosstalk: new mechanisms in the development of atherosclerosis.Frontiers in endocrinology · 2025Review
- Interventional pain management in dogs with lumbosacral stenosis: preliminary long-term clinical outcomes of combined foraminal and epidural injections with or without pulsed radiofrequency.Frontiers in veterinary science · 2025Article
- Transforaminal Steroid Injection After Dorsal Root Ganglion Pulsed Radiofrequency (DRG-PRF): Impact on Pain Intensity and Disability.Pain and therapy · 2024Article
- Pulsed Radiofrequency 2 Hz Preserves the Dorsal Root Ganglion Neuron Physiological Ca2+ Influx, Cytosolic ATP Level, Δψm, and pERK Compared to 4 Hz: An Insight on the Safety of Pulsed Radiofrequency in Pain Management [Response to Letter].Journal of pain research · 2024Article
- Pulsed Radiofrequency 2 Hz Preserves the Dorsal Root Ganglion Neuron Physiological CaJournal of pain research · 2023Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The molecular mechanism of pulsed radiofrequency (PRF) in chronic pain management is not fully understood. Chronic pain involves the activation of specific N-Methyl D-Aspartate receptors (NMDAR) to induce central sensitization. This study aims to determine the effect of PRF on central sensitization biomarker phosphorylated extracellular signal-regulated kinase (pERK), Ca Methods: This study is a true experimental in-vitro study on a sensitized DRG neuron induced with 80 µM NMDA. There are six treatment groups including control, NMDA 80 µM, Ketamine 100 µM, PRF 2Hz, NMDA 80 µM + PRF 2 Hz, and NMDA 80 µM + PRF 2 Hz + ketamine 100 µM. We use PRF 2 Hz 20 ms for 360 seconds. Statistical analysis was performed using the One-Way ANOVA and the Pearson correlation test with α=5%. Results: In the sensitized DRG neuron, there is a significant elevation of pERK. There is a strong correlation between Ca Conclusion: PRF mechanisms related to DRG neuron sensitization are by decreasing pERK, altering Ca
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Registered trials
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