ArticleFrontiers in pediatrics2023
Comprehensive analysis of untargeted metabolomics and lipidomics in girls with central precocious puberty.
Article in Frontiers in pediatrics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Embracing non-linearity in human ageing.Nature reviews. Genetics · 2026Review
- Correlation between ceramide and its metabolites and central precocious puberty: a cross-sectional study.BMC pediatrics · 2026Article
- Phenotype-specific 25-hydroxyvitamin D and fat-soluble vitamin profiles in girls with pediatric endocrine disorders: a large cross-sectional study.Frontiers in nutrition · 2026Article
- Somatotropic axis drives bone turnover heterogeneity independently of gonadotropin synergy in girls with central precocious puberty.Frontiers in endocrinology · 2026Article
- Article
- Exploring the molecular mechanism of EGCG in preventing obesity-induced precocious puberty based on serum metabolomics and molecular docking.Frontiers in nutrition · 2025Article
- Multi-omic analysis of precocious puberty girls: pathway changes and metabolite validation.Frontiers in endocrinology · 2024Article
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Authors and funding
6 authors.
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Abstract
Objective: Central precocious puberty (CPP) is a rare condition that causes early sexual development in children. Although the cure is effective, the etiology of central precocious puberty is unclear. Methods: In total, 10 girls with central precocious puberty and same number of age-matched female controls were enrolled. Plasma samples were collected from each participant and subjected to untargeted metabolomics and lipidomics. Student's Results: Fifty-nine differentially expressed metabolites were identified based on the criteria used (variable importance in the projection >1 and a Conclusion: The present study showed that antibiotic overuse, increased meat consumption, and obesity may have potential roles in the development of central precocious puberty in girls. Several metabolites have diagnostic value but further research is required.
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