Evidence map›Paper›PMID 37251917›Full record

ArticleFrontiers in oncology2023

Intragenic β-synuclein rearrangements in malignancy.

Peifang Xiao, Nan Chen, Tingting Shao, Xinni Bian, Jie Miao, Jiajia Zheng, Xingping Lang, Yiting Wang, Xiaojun Chen, Liqin Jin and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Peifang XiaoDepartment of Hematology, Children's Hospital of Soochow University, Suzhou, China.
Nan ChenDepartment of Molecular Genetics, Suzhou Sano Precision Medicine Ltd, Suzhou, China.
Tingting ShaoDepartment of Molecular Genetics, Suzhou Sano Precision Medicine Ltd, Suzhou, China.
Xinni BianDepartment of Hematology, Children's Hospital of Soochow University, Suzhou, China.
Jie MiaoDepartment of Hematology, Children's Hospital of Soochow University, Suzhou, China.
Jiajia ZhengDepartment of Hematology, Children's Hospital of Soochow University, Suzhou, China.
Xingping LangDepartment of Molecular Genetics, Suzhou Sano Precision Medicine Ltd, Suzhou, China.
Yiting WangDepartment of Molecular Genetics, Suzhou Sano Precision Medicine Ltd, Suzhou, China.
Xiaojun ChenDepartment of Molecular Genetics, Suzhou Sano Precision Medicine Ltd, Suzhou, China.
Liqin JinDepartment of Molecular Genetics, Suzhou Sano Precision Medicine Ltd, Suzhou, China.
Shaoyan HuDepartment of Hematology, Children's Hospital of Soochow University, Suzhou, China.
Sheng XiaoDepartment of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Soochow University · CNBrigham and Women's Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The synuclein family, consisting of α-, β-, and γ-synuclein, is primarily expressed in neurons. Mutations of α- and β-synuclein have been linked to Parkinson's disease and dementia with Lewy bodies, respectively. Recent studies have shown that synucleins are upregulated in various tumors, including breast, ovarian, meningioma, and melanoma, and high synuclein expression is associated with poor prognosis and drug resistance. We report a novel rearrangement of β-synuclein in a pediatric T-cell acute lymphoblastic leukemia (T-ALL) case, where β-synuclein (

Indexed as

ETV6GPRIN1SNCBsynucleinT-ALL

Identifiers

PMID37251917
PMCPMC10213389
OpenAlexW4378745108

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.