Evidence map›Paper›PMID 37251809›Full record

ArticleFrontiers in aging neuroscience2023

Mendelian randomization analyses of smoking and Alzheimer's disease in Chinese and Japanese populations.

Yuan Zhu, Ying Guan, Xuewen Xiao, Bin Jiao, Xinxin Liao, Hui Zhou, Xixi Liu, Feiyan Qi, Qiyuan Peng, Lu Zhou and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in aging neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

21 authors.

Yuan ZhuDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Ying GuanJoint Institute of Tobacco and Health, Kunming, Yunnan, China.
Xuewen XiaoDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Bin JiaoDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Xinxin LiaoEngineering Research Center of Hunan Province in Cognitive Impairment Disorders, Central South University, Changsha, China.
Hui ZhouDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Xixi LiuDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Feiyan QiJoint Institute of Tobacco and Health, Kunming, Yunnan, China.
Qiyuan PengJoint Institute of Tobacco and Health, Kunming, Yunnan, China.
Lu ZhouDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Tianyan XuDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Qijie YangDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Sizhe ZhangDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Meng LiJoint Institute of Tobacco and Health, Kunming, Yunnan, China.
Zhouhai ZhuJoint Institute of Tobacco and Health, Kunming, Yunnan, China.
Sheming LuJoint Institute of Tobacco and Health, Kunming, Yunnan, China.
Jinchen LiBioinformatics Center & National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.
Beisha TangDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Lu ShenDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Jianhua YaoJoint Institute of Tobacco and Health, Kunming, Yunnan, China.
Yafang ZhouEngineering Research Center of Hunan Province in Cognitive Impairment Disorders, Central South University, Changsha, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Previous epidemiological studies have reported controversial results on the relationship between smoking and Alzheimer's disease (AD). Therefore, we sought to assess the association using Mendelian randomization (MR) analysis. Methods: We used single nucleotide polymorphisms (SNPs) associated with smoking quantity (cigarettes per day, CPD) from genome-wide association studies (GWAS) of Japanese population as instrumental variables, then we performed two-sample MR analysis to investigate the association between smoking and AD in a Chinese cohort (1,000 AD cases and 500 controls) and a Japanese cohort (3,962 AD cases and 4,074 controls), respectively. Results: Genetically higher smoking quantity showed no statistical causal association with AD risk (the inverse variance weighted (IVW) estimate in the Chinese cohort: odds ratio (OR) = 0.510, 95% confidence interval (CI) = 0.149-1.744, Conclusion: This MR study, for the first time in Chinese and Japanese populations, found no significant association between smoking and AD.

Indexed as

Alzheimer’s diseasecausal associationEast Asian populationsmokingtwo-sample Mendelian randomization analysis

Identifiers

PMID37251809
PMCPMC10213305

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