Evidence map›Paper›PMID 37251728›Full record

Article3 Biotech2023

Schistosomicidal, hepatoprotective and antioxidant activities of the N-acetyl-L-cysteine and/or praziquantel in experimental acute mansonic schistosomiasis.

André de Lima Aires, Hallysson Douglas Andrade de Araújo, André Martins Galvão, Sidcley Bernardino de Araújo, Romildo Luciano da Silva, Zilma Pereira Dos Anjos, Maria Bernadete de Souza Maia, Valdênia Maria Oliveira Souza, Mônica Camelo Pessôa de Azevedo Albuquerque

Open access · greenAbstract read
In one paragraph

Article in 3 Biotech, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.7field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

André de Lima AiresCentro de Ciências Médicas-Área Acadêmica de Medicina Tropical, Universidade Federal de Pernambuco, Recife, Pernambuco Brazil.ORCID 0000-0001-9283-1466
Hallysson Douglas Andrade de AraújoInstituto Keizo Asami (iLIKA), Universidade Federal de Pernambuco, Recife, Pernambuco Brazil.
André Martins GalvãoCentro de Biociências, Departamento de Fisiologia e Farmacologia, Universidade Federal de Pernambuco, Recife, Pernambuco Brazil.
Sidcley Bernardino de AraújoCentro de Ciências da Saúde, Departamento de Patologia, Universidade Federal de Pernambuco, Recife, Pernambuco Brazil.
Romildo Luciano da SilvaInstituto Keizo Asami (iLIKA), Universidade Federal de Pernambuco, Recife, Pernambuco Brazil.
Zilma Pereira Dos AnjosInstituto Keizo Asami (iLIKA), Universidade Federal de Pernambuco, Recife, Pernambuco Brazil.
Maria Bernadete de Souza MaiaCentro de Biociências, Departamento de Fisiologia e Farmacologia, Universidade Federal de Pernambuco, Recife, Pernambuco Brazil.
Valdênia Maria Oliveira SouzaInstituto Keizo Asami (iLIKA), Universidade Federal de Pernambuco, Recife, Pernambuco Brazil.
Mônica Camelo Pessôa de Azevedo AlbuquerqueCentro de Ciências Médicas-Área Acadêmica de Medicina Tropical, Universidade Federal de Pernambuco, Recife, Pernambuco Brazil.
Universidade Federal de Pernambuco · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Schistosomiasis is a tropical parasitic disease, in which the major clinical manifestation includes hepatosplenomegaly, portal hypertension, and organs fibrosis. Clinically, treatment of schistosomiasis involves the use of praziquantel (PZQ) and supportive care, which does not improve the patient's outcome as liver injuries persist. Here, we report for the first time the effect of N-acetyl-L-cysteine (NAC) and/or praziquantel (PQZ) on

Indexed as

Drug associationLiverN-acetyl-L-cysteineOxidative stressSchistosoma mansoniSchistosomiasis granuloma

Identifiers

PMID37251728
PMCPMC10219907
OpenAlexW4378532788

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.