Evidence map›Paper›PMID 37251722›Full record

ArticleThe Saudi dental journal2023

Effect of multidrug solution for the treatment of chemotherapy-induced oral mucositis

Rebecca Rhuanny Tolentino Limeira, Isabella Lima Arrais Ribeiro, Paulo Rogério Ferreti Bonan, Danielle da Nóbrega Alves, Elba Dos Santos Ferreira, Tereza Karla Vieira Lopes da Costa, Cassiano Francisco Weege Nonaka, Ana Claúdia Dantas de Medeiros, Frederico Barbosa de Sousa, Ana Maria Gondim Valença and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Saudi dental journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 80% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Rebecca Rhuanny Tolentino LimeiraDepartment of Clinical and Social Dentistry, Federal University of Paraíba, Campus I, João Pessoa, PB, Brazil.
Isabella Lima Arrais RibeiroDepartment of Clinical and Social Dentistry, Federal University of Paraíba, Campus I, João Pessoa, PB, Brazil.
Paulo Rogério Ferreti BonanDepartment of Clinical and Social Dentistry, Federal University of Paraíba, Campus I, João Pessoa, PB, Brazil.
Danielle da Nóbrega AlvesDepartment of Clinical and Social Dentistry, Federal University of Paraíba, Campus I, João Pessoa, PB, Brazil.
Elba Dos Santos FerreiraDepartment of Pharmaceutical Sciences, Federal University of Paraíba, Campus I, João Pessoa, PB, Brazil.
Tereza Karla Vieira Lopes da CostaDepartment of Clinical and Social Dentistry, Federal University of Paraíba, Campus I, João Pessoa, PB, Brazil.
Cassiano Francisco Weege NonakaDepartment of Dentistry, State University of Paraíba, Campus I, Campina Grande, PB, Brazil.
Ana Claúdia Dantas de MedeirosDepartment of Pharmaceutical Sciences, State University of Paraíba, Campus I, Campina Grande, PB, Brazil.
Frederico Barbosa de SousaDepartment of Pharmaceutical Sciences, Federal University of Paraíba, Campus I, João Pessoa, PB, Brazil.
Ana Maria Gondim ValençaDepartment of Clinical and Social Dentistry, Federal University of Paraíba, Campus I, João Pessoa, PB, Brazil.
Ricardo Dias de CastroDepartment of Clinical and Social Dentistry, Federal University of Paraíba, Campus I, João Pessoa, PB, Brazil.
Universidade Federal da Paraíba · BRUniversidade Estadual da Paraíba · BRUniversidade de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Evaluate the effect of a multidrug solution, adopted by a referral hospital for cancer to control and treat chemotherapy-induced oral mucositis in rats. Methods: Oral mucositis (OM) was induced by 5-Fluorouracil (5-FU), and the animals were treated with saline (n = 8, G1), 0.12% chlorhexidine (n = 8, G2); and multidrug solution (n = 8, G3). The animals were submitted to clinical and histological analysis of the lesion using mucosal fragments. The animals' food consumption during treatment was also evaluated. Results: Clinical improvement ( Conclusions: The multidrug solution improved the clinical and histological parameters of the chemotherapy-induced oral mucositis, as well as promoted an increase in food intake.

Indexed as

CancerChemotherapyCombinationDrug TherapyOral Mucositis

Identifiers

PMID37251722
PMCPMC10213868
OpenAlexW4362635344

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.