Evidence map›Paper›PMID 37251499›Full record

ArticleComputational statistics & data analysis2023

Mediation Analysis for High-Dimensional Mediators and Outcomes with an Application to Multimodal Imaging Data.

Zhiwei Zhao, Chixiang Chen, Bhim Mani Adhikari, L Elliot Hong, Peter Kochunov, Shuo Chen

Abstract read
In one paragraph

Article in Computational statistics & data analysis, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Bayesian Image Mediation Analysis.Journal of the American Statistical Association · 2026
    Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zhiwei ZhaoDepartment of Mathematics, University of Maryland, 4176 Campus Drive, CollegePark, 20742, MD, USA.
Chixiang ChenDivision of Biostatistics and Bioinformatics, Department of Epidemiology and PublicHealth, University of Maryland School of Medicine, 655 W. Baltimore, Street, Baltimore, 21201, MD, USA.
Bhim Mani AdhikariMaryland Psychiatric Research Center, Department of Psychiatry, University ofMaryland School of Medicine, 655 W. Baltimore Street, Baltimore, 21201, MD, USA.
L Elliot HongMaryland Psychiatric Research Center, Department of Psychiatry, University ofMaryland School of Medicine, 655 W. Baltimore Street, Baltimore, 21201, MD, USA.
Peter KochunovMaryland Psychiatric Research Center, Department of Psychiatry, University ofMaryland School of Medicine, 655 W. Baltimore Street, Baltimore, 21201, MD, USA.
Shuo ChenMaryland Psychiatric Research Center, Department of Psychiatry, University ofMaryland School of Medicine, 655 W. Baltimore Street, Baltimore, 21201, MD, USA.

Funding

University of Maryland Claude D. Pepper Older Americans Independence Center (UM-OAIC)P30AG028747 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI Stephen L. Seliger · 2006 to 2026
$28.9M
SOLAR-Eclipse Computational Tools for Imaging GeneticsR01EB015611 · NIBIB · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI KOCHUNOV, PETER V. · 2012 to 2024
$5.0M
Statistical methods for vitamin D targets for functional outcomes in older adultsR01AG048069 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI SHARDELL, MICHELLE DENISE · 2015 to 2025
$4.3M
A Multivariate Mediation and Deep Learning Framework for Genome-Connectome -Substance Use ResearchDP1DA048968 · NIDA · UNIVERSITY OF MARYLAND BALTIMORE · PI CHEN, SHUO · 2019 to 2023
$2.3M
Methods to Test Biomarkers of Aging as Shared Determinants of Alzheimers Disease and Related Dementias and Physical DisabilityR01AG079854 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI SHARDELL, MICHELLE DENISE · 2023 to 2025
$2.3M
Statistical Models and Mechanisms Linking Biomarkers of Aging to Cognitive-Physical Decline and DementiaRF1NS128360 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI SHARDELL, MICHELLE DENISE · 2022 to 2022
$2.2M
Redefine Trans-Neuropsychiatric Disorder Brain Patterns through Big-Data and Machine LearningRF1MH123163 · NIMH · UNIVERSITY OF MARYLAND BALTIMORE · PI KOCHUNOV, PETER V., THOMPSON, PAUL M · 2021 to 2021
$1.2M
Hybrid GPU/CPU Computing Resource to Support Connectomic and GenomicsS10OD023696 · OD · UNIVERSITY OF MARYLAND BALTIMORE · PI KOCHUNOV, PETER V. · 2018 to 2018
$593k
NIA NIH HHS P30 AG028747NIA NIH HHS R01 AG048069NIA NIH HHS R01 AG079854NIBIB NIH HHS R01 EB015611NIDA NIH HHS DP1 DA048968NIH HHS S10 OD023696NIMH NIH HHS RF1 MH123163NINDS NIH HHS RF1 NS128360
6 · The paper itself

Abstract

Multimodal neuroimaging data have attracted increasing attention for brain research. An integrated analysis of multimodal neuroimaging data and behavioral or clinical measurements provides a promising approach for comprehensively and systematically investigating the underlying neural mechanisms of different phenotypes. However, such an integrated data analysis is intrinsically challenging due to the complex interactive relationships between the multimodal multivariate imaging variables. To address this challenge, a novel

Indexed as

bipartite graphfamily-wise error ratemultimodal imaging datamultiple-mediator multiple-outcome mediation

Identifiers

PMID37251499
PMCPMC10210585

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.