ArticleNature. Mental health2023
Precision behavioral phenotyping as a strategy for uncovering the biological correlates of psychopathology.
Article in Nature. Mental health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
71 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Childhood internalising symptoms at ages 3 and 6: a meta-analysis of epigenome-wide associations from cord and peripheral blood.Journal of child psychology and psychiatry, and allied disciplines · 2026Pooled it
- Rates of Depression in Children and Adolescents With ADHD: A Systematic Review and Meta-Analysis.Journal of attention disorders · 2025Pooled it
- Neuroimaging Insights into the Public Health Burden of Neuropsychiatric Disorders: A Systematic Review of Electroencephalography-Based Cognitive Biomarkers.Medicina (Kaunas, Lithuania) · 2025Pooled it
- The hierarchical taxonomy of psychopathology and the search for neurobiological substrates of mental illness: A systematic review and roadmap for future research.Journal of psychopathology and clinical science · 2024Pooled it
- Multivariate brain-behaviour associations in psychiatric disorders.Translational psychiatry · 2024Pooled it
- Using the Hierarchical Taxonomy of Psychopathology (HiTOP) for precision psychiatry.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2026Article
- New waves in psychiatric neuroimaging.Nature neuroscience · 2026Article
- Multiscale Heterogeneity of White Matter Morphometry in Psychiatric Disorders.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- The cross-site reproducibility of MRI morphometric phenotypes in psychiatric disorders.Nature neuroscience · 2026Article
- Commentary: Strengths remain underweighted in dimensional and transdiagnostic models of child and youth mental health: Commentary on Altschuler et al. (2026).JCPP advances · 2026Article
- A data-driven methodological framework for representative recruitment in psychiatric research: insights from the DOCUMENT study.BMC psychiatry · 2026Article
- Brain network dynamics reflect psychiatric illness status and transdiagnostic symptom profiles across health and disease.Nature communications · 2026Article
- Complex affect dynamics offer limited incremental value for cross-sectional prediction of psychological and behavioural variables in cross-validated models.BMC medicine · 2026Article
- Assessing the Psychometric Properties of the Child Behaviour Checklist in the ABCD Study.Developmental science · 2026Article
- Attention and learning strategies reveal distinct dimensions of psychiatric diseases.Research square · 2026Article
- External validation improves generalizability, replicability and reproducibility in predictive models for neuroimaging.Nature methods · 2026Review
- Advantages of combining multiple eye-tracking paradigms for distinguishing young autistic from non-autistic children.Molecular autism · 2026Article
- Can Psychiatric Genetics Advance Without Incorporating a Life Course Perspective?Biological psychiatry · 2026Review
- Cognitive arbitration between candidate dimensions of psychopathology.Molecular psychiatry · 2026Article
- Distinct Event-Related-Potential Biomarkers of Broad Versus Specific Dimensions of the Hierarchical Taxonomy of Psychopathology Externalizing Spectrum.Clinical psychological science : a journal of the Association for Psychological Science · 2026Article
11 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
Our capacity to measure diverse aspects of human biology has developed rapidly in the past decades, but the rate at which these techniques have generated insights into the biological correlates of psychopathology has lagged far behind. The slow progress is partly due to the poor sensitivity, specificity and replicability of many findings in the literature, which have in turn been attributed to small effect sizes, small sample sizes and inadequate statistical power. A commonly proposed solution is to focus on large, consortia-sized samples. Yet it is abundantly clear that increasing sample sizes will have a limited impact unless a more fundamental issue is addressed: the precision with which target behavioral phenotypes are measured. Here, we discuss challenges, outline several ways forward and provide worked examples to demonstrate key problems and potential solutions. A precision phenotyping approach can enhance the discovery and replicability of associations between biology and psychopathology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.