Evidence map›Paper›PMID 37251303›Full record

ArticleJAC-antimicrobial resistance2023

Multicentre genetic diversity study of carbapenem-resistant Enterobacterales: predominance of untypeable pUVA-like

Patricia J Simner, Yehudit Bergman, Yunfan Fan, Emily B Jacobs, Srividya Ramakrishnan, Jennifer Lu, Shawna Lewis, Ann Hanlon, Pranita D Tamma, Michael C Schatz and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JAC-antimicrobial resistance, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Patricia J SimnerDepartment of Pathology, Division of Medical Microbiology, Johns Hopkins University School of Medicine, 600 N Wolfe Street, Meyer B1-125, Baltimore, MD, USA.
Yehudit BergmanDepartment of Pathology, Division of Medical Microbiology, Johns Hopkins University School of Medicine, 600 N Wolfe Street, Meyer B1-125, Baltimore, MD, USA.
Yunfan FanDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.
Emily B JacobsDepartment of Pathology, Division of Medical Microbiology, Johns Hopkins University School of Medicine, 600 N Wolfe Street, Meyer B1-125, Baltimore, MD, USA.
Srividya RamakrishnanDepartment of Computer Science, Johns Hopkins University, Baltimore, MD, USA.ORCID https://orcid.org/0000-0001-8023-4752
Jennifer LuDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.
Shawna LewisDepartment of Pathology, Division of Medical Microbiology, Johns Hopkins University School of Medicine, 600 N Wolfe Street, Meyer B1-125, Baltimore, MD, USA.
Ann HanlonDepartment of Pathology, Division of Medical Microbiology, Johns Hopkins University School of Medicine, 600 N Wolfe Street, Meyer B1-125, Baltimore, MD, USA.
Pranita D TammaDepartment of Pediatrics, Division of Pediatric Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Michael C SchatzDepartment of Computer Science, Johns Hopkins University, Baltimore, MD, USA.
Winston TimpDepartment of Medicine, Division of Infectious Disease, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Karen C CarrollDepartment of Pathology, Division of Medical Microbiology, Johns Hopkins University School of Medicine, 600 N Wolfe Street, Meyer B1-125, Baltimore, MD, USA.
Johns Hopkins University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Carbapenem-resistant Enterobacterales (CRE) are an urgent public health threat. A better understanding of the molecular epidemiology and transmission dynamics of CRE is necessary to limit their dissemination within healthcare settings. We sought to investigate the mechanisms of resistance and spread of CRE within multiple hospitals in Maryland. Methods: From 2016 to 2018, all CRE were collected from any specimen source from The Johns Hopkins Medical Institutions. The isolates were further characterized using both phenotypic and genotypic approaches, including short- and/or long-read WGS. Results: From 2016 to 2018, 302 of 40 908 (0.7%) unique Enterobacterales isolates were identified as CRE. Of CRE, 142 (47%) were carbapenemase-producing CRE with KPC (80.3%) predominating among various genera. Significant genetic diversity was identified among all CRE with high-risk clones serving as major drivers of clonal clusters. Further, we found the predominance of pUVA-like plasmids, with a subset harbouring resistance genes to environmental cleaning agents, involved in intergenus dissemination of Conclusions: Our findings provide valuable data to understand the transmission dynamics of all CRE within the greater Maryland region. These data can help guide targeted interventions to limit CRE transmission in healthcare facilities.

Identifiers

PMID37251303
PMCPMC10214462
OpenAlexW4378376469

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.