Evidence map›Paper›PMID 37250924›Full record

ArticleHepatology forum2023

Evaluation of the effectiveness of drug-eluting transarterial chemoebolization in hepatocellular carcinoma.

Aydan Mutis Alan, Ozkan Alan, Ruslan Asadov, Coskun Ozer Demirtas, Haluk Tarik Kani, Perran Fulden Yumuk, Osman Cavit Ozdogan, Feyyaz Baltacioglu, Feyza Gunduz

Abstract read
In one paragraph

Article in Hepatology forum, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Guideline
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Aydan Mutis AlanDepartment of Internal Medicine, Marmara University School of Medicine, Istanbul, Turkiye.
Ozkan AlanDivision of Medical Oncology, Department of Internal Medicine, Marmara University School of Medicine, Istanbul, Turkiye.
Ruslan AsadovDepartment of Radiology, Marmara University School of Medicine, Istanbul, Turkiye.
Coskun Ozer DemirtasDivision of Gastroenterology, Department of Internal Medicine, Marmara University School of Medicine, Istanbul, Turkiye.
Haluk Tarik KaniDivision of Gastroenterology, Department of Internal Medicine, Marmara University School of Medicine, Istanbul, Turkiye.
Perran Fulden YumukDivision of Medical Oncology, Department of Internal Medicine, Marmara University School of Medicine, Istanbul, Turkiye.
Osman Cavit OzdoganDivision of Gastroenterology, Department of Internal Medicine, Marmara University School of Medicine, Istanbul, Turkiye.
Feyyaz BaltaciogluDepartment of Radiology, Marmara University School of Medicine, Istanbul, Turkiye.
Feyza GunduzDivision of Gastroenterology, Department of Internal Medicine, Marmara University School of Medicine, Istanbul, Turkiye.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Aim: Transarterial Chemoembolization (TACE) therapy is currently considered as first option therapy in the intermediate stage HCC. The purpose of our study is to assess the efficacy and prognostic factors related to the DEB- TACE therapy. Materials and Methods: The data from 133 patients with unresecetable HCC who were treated with DEB-TACE and followed between January 2011-March 2018 were retrospectively evaluated. To assess the efficacy of therapy, control imagings were performed at 30 Results: According to the Barcelona staging system, 16 patients (13%) were in the early stage, 58 patients (48%) were in the intermediate stage and 48 patients (39%) were in the advanced stage. There were complete response (CR) in 20 patients (17%), partial response (PR) in 36 patients (32%), stable disease (SD) in 24 patients (21%) and progressed disease (PD) in 35 (30%) patients. Median follow-up time was 14 months (range 1-77 months). Median PFS and OS were 4 months and 11 months, respectively. In multivariate analysis, posttreatment AFP ≥400 ng/ml was found to be an independent prognostic factor on both PFS and OS. Child-Pugh classification and tumor size >7 cm were independent prognostic factors on OS. Conclusion: DEB-TACE is effective and a tolerable treatment method for unresectable HCC patients.

Indexed as

DEB-TACEHepatocellular carcinomaPrognostic factors Presented as oral presentation at 12th National Hepatology Congress in Turkiye in 2019

Identifiers

PMID37250924
PMCPMC10209976

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.