Evidence map›Paper›PMID 37250908›Full record

ReviewAlzheimer's & dementia (Amsterdam, Netherlands)

Retinal imaging biomarkers of Alzheimer's disease: A systematic review and meta-analysis of studies using brain amyloid beta status for case definition.

Gizem Ashraf, Myra McGuinness, Muhammad Azaan Khan, Czarina Obtinalla, Xavier Hadoux, Peter van Wijngaarden

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Alzheimer's & dementia (Amsterdam, Netherlands). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  10. Brain and retina in Alzheimer's disease: Pathological intersections and estimates from imaging.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Review
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  12. Ocular changes as potential biomarkers for early diagnosis of Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Gizem AshrafCentre for Eye Research Australia Royal Victorian Eye and Ear Hospital Melbourne Victoria Australia.ORCID https://orcid.org/0000-0003-2629-3131
Myra McGuinnessCentre for Eye Research Australia Royal Victorian Eye and Ear Hospital Melbourne Victoria Australia.
Muhammad Azaan KhanFaculty of Medicine and Health University of New South Wales Sydney New South Wales Australia.
Czarina ObtinallaDiscipline of Orthoptics School of Allied Health Human Services & Sport College of Science Health & Engineering La Trobe University Melbourne Victoria Australia.
Xavier HadouxCentre for Eye Research Australia Royal Victorian Eye and Ear Hospital Melbourne Victoria Australia.
Peter van WijngaardenCentre for Eye Research Australia Royal Victorian Eye and Ear Hospital Melbourne Victoria Australia.ORCID https://orcid.org/0000-0002-8800-7834

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: We performed a systematic review and meta-analysis of the association between retinal imaging parameters and Alzheimer's disease (AD). Methods: PubMed, EMBASE, and Scopus were systematically searched for prospective and observational studies. Included studies had AD case definition based on brain amyloid beta (Aβ) status. Study quality assessment was performed. Random-effects meta-analyses of standardized mean difference, correlation, and diagnostic accuracy were conducted. Results: Thirty-eight studies were included. There was weak evidence of peripapillary retinal nerve fiber layer thinning on optical coherence tomography (OCT) ( Discussion: Retinal imaging parameters appear to be associated with AD. Small study sizes and heterogeneity in imaging methods and reporting make it difficult to determine utility of these changes as AD biomarkers. Highlights: We performed a systematic review on retinal imaging and Alzheimer's disease (AD).We only included studies in which cases were based on brain amyloid beta status.Several retinal biomarkers were associated with AD but clinical utility is uncertain.Studies should focus on biomarker-defined AD and use standardized imaging methods.

Indexed as

Alzheimer's diseaseamyloidbiomarkersdementiaearly detectionfundus photographyhyperspectral imagingoptical coherence tomographyoptical coherence tomography angiographyretinaretinal imaging

Identifiers

PMID37250908
PMCPMC10210353

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.