ArticleAIChE journal. American Institute of Chemical Engineers2023
Closed-loop modeling of central and intrinsic cardiac nervous system circuits underlying cardiovascular control.
Article in AIChE journal. American Institute of Chemical Engineers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 20 citations in OpenAlex.
- Multimodal, device-based therapeutic targeting of the cardiovascular autonomic nervous system.Nature reviews. Cardiology · 2026Review
- From FAIR to CURE: guidelines for computational models of biological systems.NPJ systems biology and applications · 2026Review
- Why The Polyvagal Theory Is Untenable: An international expert evaluation of the polyvagal theory and commentary upon Porges, S.W. (2025). Polyvagal theory: current status, clinical applications, and future directions. Clin. Neuropsychiatry, 22(3), 169-184.Clinical neuropsychiatry · 2026Article
- The brain-heart axis: integrative cooperation of neural, mechanical and biochemical pathways.Nature reviews. Cardiology · 2025Review
- Regulation of Cardiac Function by the Autonomic Nervous System.Physiology (Bethesda, Md.) · 2025Review
- Computational modelling of cardiac control following myocardial infarction using an in silico patient cohort.The Journal of physiology · 2025Article
- Biophysical modelling of intrinsic cardiac nervous system neuronal electrophysiology based on single-cell transcriptomics.The Journal of physiology · 2025Article
- From sampling to simulating: Single-cell multiomics in systems pathophysiological modeling.iScience · 2024Review
- Unpacking the multimodal, multi-scale data of the fast and slow lanes of the cardiac vagus through computational modelling.Experimental physiology · 2024Review
- Computational modeling of autonomic nerve stimulation: Vagus et al.Current opinion in biomedical engineering · 2024Article
- Sensitivity analysis of closed-loop one-chamber and four-chamber models with baroreflex.PLoS computational biology · 2024Article
- Systems Engineering Approach to Modeling and Analysis of Chronic Obstructive Pulmonary Disease Part II: Extension for Variable Metabolic Rates.ACS omega · 2024Article
- Systems Engineering Approach to Modeling and Analysis of Chronic Obstructive Pulmonary Disease.ACS omega · 2023Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The baroreflex is a multi-input, multi-output control physiological system that regulates blood pressure by modulating nerve activity between the brainstem and the heart. Existing computational models of the baroreflex do not explictly incorporate the intrinsic cardiac nervous system (ICN), which mediates central control of the heart function. We developed a computational model of closed-loop cardiovascular control by integrating a network representation of the ICN within central control reflex circuits. We examined central and local contributions to the control of heart rate, ventricular functions, and respiratory sinus arrhythmia (RSA). Our simulations match the experimentally observed relationship between RSA and lung tidal volume. Our simulations predicted the relative contributions of the sensory and the motor neuron pathways to the experimentally observed changes in the heart rate. Our closed-loop cardiovascular control model is primed for evaluating bioelectronic interventions to treat heart failure and renormalize cardiovascular physiology.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.