Evidence map›Paper›PMID 37250845›Full record

ArticleOpen life sciences2023

Phylogenetic analysis of promoter regions of human

Nadia Farooqi, Ataur Rahman, Yasir Ali, Kishwar Ali, Muhammad Ezaz Hasan Khan, David Aaron Jones, Mouadh Abdelkarim, Farman Ullah, Fazal Jalil

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Open life sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Nadia FarooqiDepartment of Zoology, Women Campus, University of Swat, 19120, Swat, Pakistan.
Ataur RahmanDepartment of Botany, Laboratory of Plant Ecology and Dendrochronology, University of Malakand, Khyber Pakhtunkhwa, Pakistan.
Yasir AliDepartment of Biotechnology, Faculty of Chemical and Life Sciences, Abdul Wali Khan University Mardan, 23200, Mardan, Pakistan.
Kishwar AliCollege of General Education, University of Doha for Science and Technology, Al Tarafa, Jelaiah Street, Duhail North, PO Box 24449 Doha, Qatar.
Muhammad Ezaz Hasan KhanCollege of General Education, University of Doha for Science and Technology, Al Tarafa, Jelaiah Street, Duhail North, PO Box 24449 Doha, Qatar.
David Aaron JonesCollege of Health Sciences, University of Doha for Science and Technology, Al Tarafa, Jelaiah Street, Duhail North, PO Box 24449 Doha, Qatar.
Mouadh AbdelkarimCollege of General Education, University of Doha for Science and Technology, Al Tarafa, Jelaiah Street, Duhail North, PO Box 24449 Doha, Qatar.
Farman UllahCentre for Biotechnology and Microbiology, University of Swat, 19120, Swat, Pakistan.
Fazal JalilDepartment of Biotechnology, Faculty of Chemical and Life Sciences, Abdul Wali Khan University Mardan, 23200, Mardan, Pakistan.
Qatar Science and Technology Park · QAAbdul Wali Khan University Mardan · PKUniversity of Swat · PKUniversity of Malakand · PK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Dolichol kinase (DOLK) gene encodes the polytopic DOLK protein associated with the endoplasmic reticulum (ER) N-glycosylation pathway catalyzing the final step in the biosynthesis of dolichol phosphate. Dolichol phosphate is an oligosaccharide carrier required for N-glycosylation of DOLK protein, with its deficiency leading to a severe hypo glycosylation phenotype in humans which can cause congenital disorders of glycosylation and death in early infancy. The aim of the present study is to identify the phylogenetic relationship between human and ortholog species based on their conserved sequences in DOLK gene. Sequence alignment of DOLK was carried out in this study and the evolutionarily conserved regulatory sequences were identified using bioinformatics. Promoter sequence of human DOLK was compared with orthologous sequences from different organisms. Conserved non-coding sequences (CNS) and motifs in promoter regions were found by analyzing upstream promoter sequences of

Indexed as

CDGsCNSDOLKN-glycosylation

Identifiers

PMID37250845
PMCPMC10224619
OpenAlexW4378085272

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.