Evidence map›Paper›PMID 37250635›Full record

ArticleFrontiers in medicine2023

Region-specific deep learning models for accurate segmentation of rectal structures on post-chemoradiation T2w MRI: a multi-institutional, multi-reader study.

Thomas DeSilvio, Jacob T Antunes, Kaustav Bera, Prathyush Chirra, Hoa Le, David Liska, Sharon L Stein, Eric Marderstein, William Hall, Rajmohan Paspulati and 3 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 1 country.

Thomas DeSilvioDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States.
Jacob T AntunesDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States.
Kaustav BeraDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States.
Prathyush ChirraDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States.
Hoa LeDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States.
David LiskaDepartment of Colorectal Surgery, Cleveland Clinic, Cleveland, OH, United States.
Sharon L SteinDepartment of Surgery, University Hospitals Cleveland Medical Center, Cleveland, OH, United States.
Eric MardersteinNortheast Ohio Veterans Affairs Medical Center, Cleveland, OH, United States.
William HallDepartment of Radiation Oncology and Surgery, Medical College of Wisconsin, Milwaukee, WI, United States.
Rajmohan PaspulatiDepartment of Diagnostic Imaging and Interventional Radiology, Moffitt Cancer Center, Tampa, FL, United States.
Jayakrishna GollamudiDepartment of Radiology, University of Cincinnati, Cincinnati, OH, United States.
Andrei S PuryskoSection of Abdominal Imaging and Nuclear Radiology Department, Cleveland Clinic, Cleveland, OH, United States.
Satish E ViswanathDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States.
Case Western Reserve University · USCleveland Clinic · USMedical College of Wisconsin · USMoffitt Cancer Center · USUniversity Hospitals of Cleveland · USUniversity of Cincinnati · USVA Northeast Ohio Healthcare System · US

Funding

Interdisciplinary Biomedical Imaging Training ProgramT32EB007509 · NIBIB · CASE WESTERN RESERVE UNIVERSITY · PI DAVID Lynn WILSON, Xin Yu · 2007 to 2026
$5.6M
RadxTools for assessing tumor treatment response on imagingU01CA248226 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI TIWARI, PALLAVI, VISWANATH, SATISH EASWAR · 2020 to 2022
$1.4M
Rad-path-omic tools for rectal cancer treatment evaluationF31CA216935 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI ANTUNES, JACOB · 2019 to 2020
$71k
Radiomics-based Risk Prediction for Therapy Selection in Crohn’s Disease via MRIF31DK130587 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI CHIRRA, PRATHYUSH V · 2022 to 2022
$35k
NCI NIH HHS F31 CA216935NCI NIH HHS U01 CA248226NIBIB NIH HHS T32 EB007509NIDDK NIH HHS F31 DK130587
6 · The paper itself

Abstract

Introduction: For locally advanced rectal cancers, Methods: This study presents the application of U-Net deep learning models that have been uniquely developed with region-specific context to automatically segment each of the outer rectal wall, lumen, and perirectal fat regions on post-treatment, T Results: In multi-institutional evaluation, region-specific U-Nets (wall Dice = 0.920, lumen Dice = 0.895) were found to perform comparably to multiple readers (wall inter-reader Dice = 0.946, lumen inter-reader Dice = 0.873). Additionally, when compared to a multi-class U-Net, region-specific U-Nets yielded an average 20% improvement in Dice scores for segmenting each of the wall, lumen, and fat; even when tested on T Discussion: Developing deep learning segmentation models with region-specific context may thus enable highly accurate, detailed annotations for multiple rectal structures on post-chemoradiation T

Indexed as

artificial intelligence (AI)deep learningMRIrectal cancer (RC)segmentationU-Net

Identifiers

PMID37250635
PMCPMC10213753
OpenAlexW4376279090

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.