ArticleNature. Mental health2023
Multivariate genome-wide association meta-analysis of over 1 million subjects identifies loci underlying multiple substance use disorders.
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Article in Nature. Mental health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 173 papers, 6 of them syntheses that pooled it.
0numbers the graph read from it
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173citing papers in PubMed, 6 pooled it
65.1field-weighted citation impact, top 1% of its field
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Who cites it
173 citing papers in PubMed, 6 syntheses or guidelines pooled it, 212 citations in OpenAlex.
- Does illicit drug use increase stroke risk? A systematic review, meta-analyses, and Mendelian randomization analysis.International journal of stroke : official journal of the International Stroke Society · 2026Pooled it
- Genome-wide meta-analyses of cross substance use disorders in diverse populations.Molecular psychiatry · 2026Pooled it
- The Genetic Architecture of the Human Corpus Callosum and its Subregions.Nature communications · 2025Pooled it
- Multi-ancestry meta-analysis of tobacco use disorder identifies 461 potential risk genes and reveals associations with multiple health outcomes.Nature human behaviour · 2024Pooled it
- GenomeMUSter mouse genetic variation service enables multitrait, multipopulation data integration and analysis.Genome research · 2024Pooled it
- Genome-wide association study in individuals of European and African ancestry and multi-trait analysis of opioid use disorder identifies 19 independent genome-wide significant risk loci.Molecular psychiatry · 2022Pooled it
- The clinical usefulness of knowingTumori · 2026Trial
- Big data and psychiatry: advances, constraints and future directions.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2026Article
- A single-nuclei multiomics resource across four brain regions prioritises human neural cell types influencing brain-related traits.bioRxiv : the preprint server for biology · 2026Article
- Polysubstance use disorders among US adults.Molecular psychiatry · 2026Article
- Genomic dimensions deconstruct the clinical heterogeneity of bipolar disorder.Research square · 2026Article
- Influence of Translocator Protein (Life (Basel, Switzerland) · 2026Article
- The quantitative economon model as a novel computational tool for addiction research.Experimental and clinical psychopharmacology · 2026Article
- Exploratory Genome and Transcriptome-Wide Association Analyses of Addiction-Related Phenotypes in a Twin Cohort.Biomedicines · 2026Article
- Glucagon-like peptide-1 receptor activation and mental health: a drug-target mendelian randomization study.Translational psychiatry · 2026Article
- Transcriptional Response to Chronic Long-Access Fentanyl Self-Administration in Rat Habenula and Amygdala.Addiction biology · 2026Article
- A Bayesian Learning Model for Joint Risk Prediction of Alcohol and Cannabis Use Disorders.Statistics in medicine · 2026Article
- Regulatory mechanisms driven by functional 3'-UTR variants in alcohol use disorder and related traits.Genome biology · 2026Article
- Fine-mapping candidate neuropsychiatric regulatory variants using cell type-aware comparative genomics.bioRxiv : the preprint server for biology · 2026Article
- Genome-wide association study of cocaine self-administration behavior in Heterogeneous Stock rats.Nature communications · 2026Article
113 more citing papers are in PubMed but not listed here.
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Authors and funding
23 authors at 20 institutions in 12 countries.
Alexander S HatoumWashington University School of Medicine, Department of Psychiatry, Saint Louis, USA.
Sarah M C ColbertWashington University School of Medicine, Department of Psychiatry, Saint Louis, USA.
Emma C JohnsonWashington University School of Medicine, Department of Psychiatry, Saint Louis, USA.
Spencer B HuggettEmory University, Department of Psychology.
Joseph D DeakDepartment of Psychiatry, Division of Human Genetics, Yale School of Medicine, New Haven, CT, USA.
Gita PathakDepartment of Psychiatry, Division of Human Genetics, Yale School of Medicine, New Haven, CT, USA.
Mariela V JenningsUC San Diego School of Medicine, Department of Psychiatry, San Diego, CA, USA.
Sarah E PaulDepartment of Psychological & Brain Sciences, Washington University in St. Louis.
Nicole R KarcherWashington University School of Medicine, Department of Psychiatry, Saint Louis, USA.
Isabella HansenDepartment of Psychological & Brain Sciences, Washington University in St. Louis.
David A A BarangerWashington University School of Medicine, Department of Psychiatry, Saint Louis, USA.
Alexis EdwardsVirginia Institute of Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA.
Andrew GrotzingerUniversity of Colorado-Boulder, Institute for Behavioral Genetics, Boulder, CO, USA.
Substance Use Disorder Working Group of the Psychiatric Genomics Consortium
Elliot M Tucker-DrobUniversity of Texas at Austin, Department of Psychology and Population Research Center, Austin, TX, USA.
Henry R KranzlerCenter for Studies of Addiction, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Lea K DavisDepartment of Medicine, Division of Genetic Medicine, Vanderbilt University, Nashville, TN, USA.
Sandra Sanchez-RoigeUC San Diego School of Medicine, Department of Psychiatry, San Diego, CA, USA.
Renato PolimantiDepartment of Psychiatry, Division of Human Genetics, Yale School of Medicine, New Haven, CT, USA.
Joel GelernterDepartment of Psychiatry, Division of Human Genetics, Yale School of Medicine, New Haven, CT, USA.
Howard J EdenbergDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.
Ryan BogdanDepartment of Psychological & Brain Sciences, Washington University in St. Louis.
Arpana AgrawalWashington University School of Medicine, Department of Psychiatry, Saint Louis, USA.
Washington University in St. Louis · USVirginia Commonwealth University · USHeidelberg University · DEUniversity of Colorado Boulder · USUniversity of Helsinki · FIBroad Institute · USQIMR Berghofer Medical Research Institute · AUUniversity of Bonn · DEUniversity of Minnesota · USYale University · USMayo Clinic · USMedical University of Vienna · ATUniversity of California San Diego · USUniversity of Otago · NZVrije Universiteit Amsterdam · NLKing's College London · GBMax Planck Institute of Psychiatry · DERutgers, The State University of New Jersey · USUniversity of Pittsburgh · USBoston University · US
Funding
23/24 Healthy Brain and Child Development National ConsortiumU01DA055367 · NIDA · WASHINGTON UNIVERSITY · PI RYAN H BOGDAN, CYNTHIA Elise ROGERS · 2021 to 2026
$10.8MBIOMEDICAL RESEARCH TRAINING IN DRUG ABUSET32DA007261 · NIDA · WASHINGTON UNIVERSITY · PI ARPANA AGRAWAL, Jose A Moron-Concepcion · 1991 to 2026
$8.8MPopulation Research CenterR24HD042849 · NICHD · UNIVERSITY OF TEXAS AUSTIN · PI HAYWARD, MARK D. · 2002 to 2016
$8.4MRESEARCH TRAINING - BIOLOGICAL SCIENCEST32MH014276 · NIMH · YALE UNIVERSITY · PI Marina R Picciotto · 1985 to 2026
$7.2MProgram Development and Pilot CoreP30AG066614 · NIA · UNIVERSITY OF TEXAS AT AUSTIN · PI KAREN L FINGERMAN · 2020 to 2026
$5.2MScientific & Technical CoreP2CHD042849 · NICHD · UNIVERSITY OF TEXAS AT AUSTIN · PI MARK D. HAYWARD · 2017 to 2026
$5.2MThe Etiology of Risk: Alcohol Use Disorder and Suicidal BehaviorR01AA027522 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI Alexis C Edwards, Kristina Sundquist · 2019 to 2026
$3.5M7/7 Psychiatric Genomics Consortium: Advancing Discovery and ImpactR01DA054869 · NIDA · WASHINGTON UNIVERSITY · PI AGRAWAL, ARPANA, EDENBERG, HOWARD J · 2021 to 2025
$3.3MDissecting the Multivariate Genetic Architecture of Psychiatric DiseasesR01MH120219 · NIMH · UNIVERSITY OF TEXAS AT AUSTIN · PI NIVARD, MICHEL GUILLAUME, TUCKER-DROB, ELLIOT MAX · 2020 to 2024
$3.3MBuilding Bridges to Allow Cross-species Translational genetics for the Study of AddictionDP1DA054394 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SANCHEZ ROIGE, SANDRA · 2021 to 2025
$2.4MLarge-Scale Genomic Analysis of Aging-Related Cognitive Change Prior to Dementia OnsetRF1AG073593 · NIA · UNIVERSITY OF TEXAS AT AUSTIN · PI TUCKER-DROB, ELLIOT MAX · 2021 to 2021
$2.1MInvestigating the Systems Genetics of the Patterns of Polysubstance Abuse and AddictionR33DA047527 · NIDA · YALE UNIVERSITY · PI POLIMANTI, RENATO · 2021 to 2023
$2.0MMedical Research Council MR/W030608/1NIAAA NIH HHS F31 AA029934NIAAA NIH HHS K01 AA030083NIAAA NIH HHS R01 AA027522NIAAA NIH HHS R21 AA027827NIAAA NIH HHS T32 AA028259NIA NIH HHS P30 AG066614NIA NIH HHS RF1 AG073593NICHD NIH HHS P2C HD042849NICHD NIH HHS R24 HD042849NIDA NIH HHS DP1 DA054394NIDA NIH HHS K01 DA051759NIDA NIH HHS K02 DA032573NIDA NIH HHS R01 DA054750NIDA NIH HHS R01 DA054869NIDA NIH HHS R33 DA047527NIDA NIH HHS T32 DA007261NIDA NIH HHS U01 DA055367NIMH NIH HHS K23 MH121792NIMH NIH HHS R01 MH120219NIMH NIH HHS T32 MH014276
Abstract
Genetic liability to substance use disorders can be parsed into loci that confer general or substance-specific addiction risk. We report a multivariate genome-wide association meta-analysis that disaggregates general and substance-specific loci for published summary statistics of problematic alcohol use, problematic tobacco use, cannabis use disorder, and opioid use disorder in a sample of
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.