Evidence map›Paper›PMID 37250390›Full record

ArticleFrontiers in neuroscience2023

Persistent olfactory dysfunction associated with poor sleep quality and anxiety in patients with long COVID.

Alna Carolina Mendes Paranhos, Apio Ricardo Nazareth Dias, Thalita da Rocha Bastos, Arthur Nascimento Rodrigues, Karem Harumy Yamamoto Santana, Lorena Henriete Araujo Dias, Lidiane Palheta Miranda Dos Santos, Antônio José Cerasi, Michely Caroline Nascimento Mendes, Cleiziane Lima de Oliveira and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Psychological Distress in Patients with Long-lasting COVID-19 Olfactory Dysfunction.Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 1 country.

Alna Carolina Mendes ParanhosHealth and Biological Science Center, State University of Pará, Pará, Brazil.
Apio Ricardo Nazareth DiasHealth and Biological Science Center, State University of Pará, Pará, Brazil.
Thalita da Rocha BastosHealth and Biological Science Center, State University of Pará, Pará, Brazil.
Arthur Nascimento RodriguesHealth and Biological Science Center, State University of Pará, Pará, Brazil.
Karem Harumy Yamamoto SantanaHealth and Biological Science Center, State University of Pará, Pará, Brazil.
Lorena Henriete Araujo DiasHealth and Biological Science Center, State University of Pará, Pará, Brazil.
Lidiane Palheta Miranda Dos SantosHealth and Biological Science Center, State University of Pará, Pará, Brazil.
Antônio José CerasiBiological Science Center, Federal University of Pará, Pará, Brazil.
Michely Caroline Nascimento MendesHealth and Biological Science Center, State University of Pará, Pará, Brazil.
Cleiziane Lima de OliveiraHealth and Biological Science Center, State University of Pará, Pará, Brazil.
Mariângela Moreno DominguesHealth and Biological Science Center, State University of Pará, Pará, Brazil.
Gisele Vieira Hennemann KouryHealth and Biological Science Center, State University of Pará, Pará, Brazil.
Pedro Fernando da Costa VasconcelosHealth and Biological Science Center, State University of Pará, Pará, Brazil.
Givago Silva SouzaTropical Medicine Center, Federal University of Pará, Pará, Brazil.
Juarez Antônio Simões QuaresmaHealth and Biological Science Center, State University of Pará, Pará, Brazil.
Luiz Fábio Magno FalcãoHealth and Biological Science Center, State University of Pará, Pará, Brazil.
Universidade do Estado do Pará · BRHospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo · BRUniversidade Federal do Pará · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Poor sleep quality have been widely reported in patients with long COVID. Determining the characteristics, type, severity, and relationship of long COVID with other neurological symptoms is essential for the prognosis and management of poor sleep quality. Methods: This cross-sectional study was conducted at a public university in the eastern Amazon region of Brazil between November 2020 and October 2022. The study involved 288 patients with long COVID with self-report neurological symptoms. One hundred thirty-one patients were evaluated by using standardised protocols: Pittsburgh sleep quality index (PSQI), Beck Anxiety Inventory, Chemosensory Clinical Research Center (CCRC), and Montreal Cognitive Assessment (MoCA). This study aimed to describe the sociodemographic and clinical characteristics of patients with long COVID with poor sleep quality and their relationship with other neurological symptoms (anxiety, cognitive impairment, and olfactory disorder). Results: Patients with poor sleep quality were mainly women (76.3%), 44.04 ± 12.73 years old, with >12 years of education (93.1%), and had monthly incomes of up to US $240.00 (54.2%). Anxiety and olfactory disorder were more common in patients with poor sleep quality. Discussion: Multivariate analysis shows that the prevalence of poor sleep quality was higher in patients with anxiety, and olfactory disorder is associated with poor sleep quality. In this cohort of patients with long COVID, the prevalence of poor sleep quality was highest in the group tested by PSQI and were associated with other neurological symptoms, such as anxiety and olfactory dysfunction. A previous study indicates a significant association between poor sleep quality and psychological disorders over time. Recent studies involving neuroimaging found functional and structural changes in Long COVID patients with persistent olfactory disfunction. Poor sleep quality are integral part of complex changes related to Long COVID and should be part of patient's clinical management.

Indexed as

anxietylong COVIDneurological manifestationsolfaction disorderssleep disorders

Identifiers

PMID37250390
PMCPMC10213228
OpenAlexW4376255601

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.