Evidence map›Paper›PMID 37250335›Full record

ArticleiScience2023

eIF4E phosphorylation recruits β-catenin to mRNA cap and promotes Wnt pathway translation in dentate gyrus LTP maintenance.

Sudarshan Patil, Kleanthi Chalkiadaki, Tadiwos F Mergiya, Konstanze Krimbacher, Inês S Amorim, Shreeram Akerkar, Christos G Gkogkas, Clive R Bramham

Open access · goldAbstract read
In one paragraph

Article in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Sudarshan PatilDepartment of Biomedicine Jonas Lies vei 91, University of Bergen, 5009 Bergen, Norway.
Kleanthi ChalkiadakiBiomedical Research Institute, Foundation for Research and Technology-Hellas, 45110 Ioannina, Greece.
Tadiwos F MergiyaDepartment of Biomedicine Jonas Lies vei 91, University of Bergen, 5009 Bergen, Norway.
Konstanze KrimbacherCenter for Discovery Brain Sciences, University of Edinburgh, EH8 9XD Edinburgh, UK.
Inês S AmorimCenter for Discovery Brain Sciences, University of Edinburgh, EH8 9XD Edinburgh, UK.
Shreeram AkerkarDepartment of Biomedicine Jonas Lies vei 91, University of Bergen, 5009 Bergen, Norway.
Christos G GkogkasBiomedical Research Institute, Foundation for Research and Technology-Hellas, 45110 Ioannina, Greece.
Clive R BramhamDepartment of Biomedicine Jonas Lies vei 91, University of Bergen, 5009 Bergen, Norway.
University of Bergen · NOFoundation for Research and Technology Hellas · GRUniversity of Edinburgh · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The mRNA cap-binding protein, eukaryotic initiation factor 4E (eIF4E), is crucial for translation and regulated by Ser209 phosphorylation. However, the biochemical and physiological role of eIF4E phosphorylation in translational control of long-term synaptic plasticity is unknown. We demonstrate that phospho-ablated

Indexed as

Cell biologyMolecular biology

Identifiers

PMID37250335
PMCPMC10214474
OpenAlexW4365816017

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.