ArticleiScience2023
Exploration behavior after reversals is predicted by STN-GPe synaptic plasticity in a basal ganglia model.
Article in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Cognitive functions of the GPe.Trends in neurosciences · 2026Review
- Basal ganglia deep brain stimulation restores cognitive flexibility and exploration-exploitation balance disrupted by NMDA-R antagonism.Nature communications · 2025Article
- Pallidal Deep Brain Stimulation Enhances Habitual Behavior in a Neuro-Computational Basal Ganglia Model During a Reward Reversal Learning Task.The European journal of neuroscience · 2025Article
- Quantitative Systems Pharmacology Development and Application in Neuroscience.Handbook of experimental pharmacology · 2025Review
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Authors and funding
4 authors.
Funding
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Abstract
Humans can quickly adapt their behavior to changes in the environment. Classical reversal learning tasks mainly measure how well participants can disengage from a previously successful behavior but not how alternative responses are explored. Here, we propose a novel 5-choice reversal learning task with alternating position-reward contingencies to study exploration behavior after a reversal. We compare human exploratory saccade behavior with a prediction obtained from a neuro-computational model of the basal ganglia. A new synaptic plasticity rule for learning the connectivity between the subthalamic nucleus (STN) and external globus pallidus (GPe) results in exploration biases to previously rewarded positions. The model simulations and human data both show that during experimental experience exploration becomes limited to only those positions that have been rewarded in the past. Our study demonstrates how quite complex behavior may result from a simple sub-circuit within the basal ganglia pathways.
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Registered trials
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