Evidence map›Paper›PMID 37250272›Full record

ArticleJournal of cell science & therapy2023

Impact of Needle Selection on Survival of Muscle-Derived Cells When Used for Laryngeal Injections.

Oluwaseyi Awonusi, Zachary J Harbin, Sarah Brookes, Lujuan Zhang, Samuel Kaefer, Rachel A Morrison, Sharlé Newman, Sherry Voytik-Harbin, Stacey Halum

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in Journal of cell science & therapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Oluwaseyi AwonusiDepartment of Otolaryngology-Head and Neck Surgery, Indiana University School of Medicine (IUSM), Indianapolis, IN, USA.
Zachary J HarbinSchool of Mechanical Engineering, Purdue University, West Lafayette, IN, USA.
Sarah BrookesWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA.
Lujuan ZhangDepartment of Otolaryngology-Head and Neck Surgery, Indiana University School of Medicine (IUSM), Indianapolis, IN, USA.
Samuel KaeferDepartment of Otolaryngology-Head and Neck Surgery, Indiana University School of Medicine (IUSM), Indianapolis, IN, USA.
Rachel A MorrisonWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA.
Sharlé NewmanDepartment of Otolaryngology-Head and Neck Surgery, Indiana University School of Medicine (IUSM), Indianapolis, IN, USA.
Sherry Voytik-HarbinWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA.
Stacey HalumDepartment of Otolaryngology-Head and Neck Surgery, Indiana University School of Medicine (IUSM), Indianapolis, IN, USA.
Indiana University Health · USPurdue University West Lafayette · USIndiana University – Purdue University Indianapolis · US

Funding

Muscle progenitor cell-based implants for dynamic laryngeal muscle reconstructionR01DC014070 · NIDCD · PURDUE UNIVERSITY · PI HALUM, STACEY L. · 2015 to 2024
$4.9M
Cellular Reinnervation Therapy for Vocal Fold ParalysisR01DC019632 · NIDCD · INDIANA UNIVERSITY INDIANAPOLIS · PI HALUM, STACEY L., VOYTIK-HARBIN, SHERRY L · 2021 to 2025
$3.2M
NIDCD NIH HHS R01 DC014070NIDCD NIH HHS R01 DC019632
6 · The paper itself

Abstract

Objective: To describe how differing injector needles and delivery vehicles impact Autologous Muscle-Derived Cell (AMDC) viability when used for laryngeal injection. Methods: In this study, adult porcine muscle tissue was harvested and used to create AMDC populations. While controlling cell concentration (1 × 10 Results: The viability of cells post-injection was not impacted by needle length or needle gauge but was significantly impacted by the delivery vehicle. Overall, injection of cells using collagen as a delivery vehicle maintained the highest cell viability. Conclusion: Needle gauge, needle length, and delivery vehicle are important factors that can affect the viability of injected cell populations. These factors should be considered and adapted to improve injectable MDC therapy outcomes when used for laryngeal applications.

Indexed as

Autologous muscle-derived cellsBiomaterialsCell viabilityInjection needleMuscle progenitor cellsStem cells

Identifiers

PMID37250272
PMCPMC10217785
OpenAlexW4378745423

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.