Evidence map›Paper›PMID 37250172›Full record

ArticleActa pharmaceutica Sinica. B2023

8-Hydroxyquinolylnitrones as multifunctional ligands for the therapy of neurodegenerative diseases.

Damijan Knez, Daniel Diez-Iriepa, Mourad Chioua, Andrea Gottinger, Milica Denic, Fabien Chantegreil, Florian Nachon, Xavier Brazzolotto, Anna Skrzypczak-Wiercioch, Anže Meden and 13 more

Open access · diamondAbstract read
In one paragraph

Article in Acta pharmaceutica Sinica. B, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
9.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 39 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 8 institutions in 4 countries.

Damijan KnezUniversity of Ljubljana, Faculty of Pharmacy, Ljubljana 1000, Slovenia.
Daniel Diez-IriepaLaboratory of Medicinal Chemistry (Institute of Organic Chemistry, CSIC); Madrid 28006, Spain.
Mourad ChiouaLaboratory of Medicinal Chemistry (Institute of Organic Chemistry, CSIC); Madrid 28006, Spain.
Andrea GottingerDepartment of Biology and Biotechnology, University of Pavia, Pavia 27100, Italy.
Milica DenicDépartement de Toxicologie et Risques Chimiques, Institut de Recherche Biomédicale des Armées, Paris 91220, France.
Fabien ChantegreilDépartement de Toxicologie et Risques Chimiques, Institut de Recherche Biomédicale des Armées, Paris 91220, France.
Florian NachonDépartement de Toxicologie et Risques Chimiques, Institut de Recherche Biomédicale des Armées, Paris 91220, France.
Xavier BrazzolottoDépartement de Toxicologie et Risques Chimiques, Institut de Recherche Biomédicale des Armées, Paris 91220, France.
Anna Skrzypczak-WierciochDepartment of Animal Anatomy and Preclinical Sciences, University Centre of Veterinary Medicine JU-UA, University of Agriculture in Krakow, Krakow 30-059, Poland.
Anže MedenUniversity of Ljubljana, Faculty of Pharmacy, Ljubljana 1000, Slovenia.
Anja PišlarUniversity of Ljubljana, Faculty of Pharmacy, Ljubljana 1000, Slovenia.
Janko KosUniversity of Ljubljana, Faculty of Pharmacy, Ljubljana 1000, Slovenia.
Simon ŽakeljUniversity of Ljubljana, Faculty of Pharmacy, Ljubljana 1000, Slovenia.
Jure StojanInstitute of Biochemistry, Faculty of Medicine, University of Ljubljana, Ljubljana 1000, Slovenia.
Kinga SałatDepartment of Pharmacodynamics, Chair of Pharmacodynamics, Faculty of Pharmacy, Jagiellonian University Medical College, Krakow 30-688, Poland.
Julia SerranoDepartment of Translational Neurobiology, Neurovascular Research Group, Cajal Institute (CSIC), Madrid 28002, Spain.
Ana Patricia FernándezDepartment of Translational Neurobiology, Neurovascular Research Group, Cajal Institute (CSIC), Madrid 28002, Spain.
Aitana Sánchez-GarcíaBiotechnology and Vegetal Biology Department, Escuela Técnica Superior de Ingeniería Agronómica, Alimentaria y de Biosistemas, Universidad Politécnica de Madrid, Madrid 28040, Spain.
Ricardo Martínez-MurilloDepartment of Translational Neurobiology, Neurovascular Research Group, Cajal Institute (CSIC), Madrid 28002, Spain.
Claudia BindaDepartment of Biology and Biotechnology, University of Pavia, Pavia 27100, Italy.
Francisco López-MuñozFaculty of Health, Camilo José Cela University of Madrid (UCJC), Neuropsychopharmacology Unit, "Hospital 12 de Octubre" Research Institute, Madrid 28692, Spain.
Stanislav GobecUniversity of Ljubljana, Faculty of Pharmacy, Ljubljana 1000, Slovenia.
José Marco-ContellesLaboratory of Medicinal Chemistry (Institute of Organic Chemistry, CSIC); Madrid 28006, Spain.
University of Ljubljana · SIInstituto Cajal · ESInstituto de Química Orgánica General · ESUniversity of Pavia · ITCamilo José Cela University · ESJagiellonian University · PLUniversidad Politécnica de Madrid · ESUniversity of Agriculture in Krakow · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We describe the development of quinolylnitrones (QNs) as multifunctional ligands inhibiting cholinesterases (ChEs: acetylcholinesterase and butyrylcholinesterase-hBChE) and monoamine oxidases (hMAO-A/B) for the therapy of neurodegenerative diseases. We identified QN

Indexed as

6-Hydroxydopamine modelAlzheimer's diseaseButyrylcholinesteraseMonoamine oxidase BMultifunctional ligandsNovel object recognitionPassive avoidance taskQuinolylnitrone

Identifiers

PMID37250172
PMCPMC10213797
OpenAlexW4317473419

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.