Evidence map›Paper›PMID 37250164›Full record

ArticleActa pharmaceutica Sinica. B2023

Cell-derived nanovesicles from mesenchymal stem cells as extracellular vesicle-mimetics in wound healing.

Yub Raj Neupane, Harish K Handral, Syed Abdullah Alkaff, Wei Heng Chng, Gopalakrishnan Venkatesan, Chenyuan Huang, Choon Keong Lee, Jiong-Wei Wang, Gopu Sriram, Rhonnie Austria Dienzo and 4 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta pharmaceutica Sinica. B, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 51 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Yub Raj NeupaneDepartment of Pharmacy, National University of Singapore, Singapore 117559, Singapore.
Harish K HandralDepartment of Mechanical Engineering, National University of Singapore, Singapore 117575, Singapore.
Syed Abdullah AlkaffSchool of Materials Science and Engineering, Nanyang Technological University, Singapore 639798, Singapore.
Wei Heng ChngDepartment of Pharmacy, National University of Singapore, Singapore 117559, Singapore.
Gopalakrishnan VenkatesanDepartment of Pharmacy, National University of Singapore, Singapore 117559, Singapore.
Chenyuan HuangDepartment of Surgery, National University of Singapore, Singapore 119228, Singapore.
Choon Keong LeeDepartment of Pharmacy, National University of Singapore, Singapore 117559, Singapore.
Jiong-Wei WangDepartment of Surgery, National University of Singapore, Singapore 119228, Singapore.
Gopu SriramFaculty of Dentistry, National University of Singapore, Singapore 119085, Singapore.
Rhonnie Austria DienzoLee Kong Chian School of Medicine, Nanyang Technological University, Singapore 639798, Singapore.
Wen Feng LuDepartment of Mechanical Engineering, National University of Singapore, Singapore 117575, Singapore.
Yusuf AliLee Kong Chian School of Medicine, Nanyang Technological University, Singapore 639798, Singapore.
Bertrand CzarnySchool of Materials Science and Engineering, Nanyang Technological University, Singapore 639798, Singapore.
Giorgia PastorinDepartment of Pharmacy, National University of Singapore, Singapore 117559, Singapore.
National University of Singapore · SGNanyang Technological University · SGUniversity of Iowa · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Wound healing is a dynamic process that involves a series of molecular and cellular events aimed at replacing devitalized and missing cellular components and/or tissue layers. Recently, extracellular vesicles (EVs), naturally cell-secreted lipid membrane-bound vesicles laden with biological cargos including proteins, lipids, and nucleic acids, have drawn wide attention due to their ability to promote wound healing and tissue regeneration. However, current exploitation of EVs as therapeutic agents is limited by their low isolation yields and tedious isolation processes. To circumvent these challenges, bioinspired cell-derived nanovesicles (CDNs) that mimic EVs were obtained by shearing mesenchymal stem cells (MSCs) through membranes with different pore sizes. Physical characterisations and high-throughput proteomics confirmed that MSC-CDNs mimicked MSC-EVs. Moreover, these MSC-CDNs were efficiently uptaken by human dermal fibroblasts and demonstrated a dose-dependent activation of MAPK signalling pathway, resulting in enhancement of cell proliferation, cell migration, secretion of growth factors and extracellular matrix proteins, which all promoted tissue regeneration. Of note, MSC-CDNs enhanced angiogenesis in human dermal microvascular endothelial cells in a 3D PEG-fibrin scaffold and animal model, accelerating wound healing

Indexed as

BionanotechnologyCell-derived nanovesiclesCell migrationCell proliferationECMExtracellular vesiclesFibroblastsMesenchymal stem cellsWound healing

Identifiers

PMID37250164
PMCPMC10213815
OpenAlexW4309027732

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.