Evidence map›Paper›PMID 37250160›Full record

ArticleActa pharmaceutica Sinica. B2023

Supramolecular approaches for insulin stabilization without prolonged duration of action.

Rolande Meudom, Yanxian Zhang, Michael A VandenBerg, Lei Zou, Yi Wolf Zhang, Matthew J Webber, Danny Hung-Chieh Chou

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta pharmaceutica Sinica. B, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Enhanced radiotheranostic targeting of integrinActa pharmaceutica Sinica. B · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Rolande MeudomDivision of Endocrinology and Diabetes, Department of Pediatrics, School of Medicine, Stanford University, Palo Alto, CA 94305, USA.
Yanxian ZhangDivision of Endocrinology and Diabetes, Department of Pediatrics, School of Medicine, Stanford University, Palo Alto, CA 94305, USA.
Michael A VandenBergDepartment of Chemical Engineering, University of Notre Dame, Notre Dame, IN 46556, USA.
Lei ZouDepartment of Chemical Engineering, University of Notre Dame, Notre Dame, IN 46556, USA.
Yi Wolf ZhangDivision of Endocrinology and Diabetes, Department of Pediatrics, School of Medicine, Stanford University, Palo Alto, CA 94305, USA.
Matthew J WebberDepartment of Chemical Engineering, University of Notre Dame, Notre Dame, IN 46556, USA.
Danny Hung-Chieh ChouDivision of Endocrinology and Diabetes, Department of Pediatrics, School of Medicine, Stanford University, Palo Alto, CA 94305, USA.
University of Notre Dame · USUniversity of Utah · USStanford University · US

Funding

Development of long-acting glucose-responsive insulin formulationsR01DK121336 · NIDDK · STANFORD UNIVERSITY · PI CHOU, DANNY HUNG-CHIEH · 2020 to 2023
$2.5M
DEVELOPMENT OF CONCENTRATED, STABLE ULTRA FAST-ACTING INSULIN FORMULATIONR01DK120430 · NIDDK · UNIVERSITY OF UTAH · PI CHOU, DANNY HUNG-CHIEH · 2018 to 2021
$2.2M
NIDDK NIH HHS R01 DK120430NIDDK NIH HHS R01 DK121336
6 · The paper itself

Abstract

Aggregation represents a significant challenge for the long-term formulation stability of insulin therapeutics. The supramolecular PEGylation of insulin with conjugates of cucurbit[7]uril and polyethylene glycol (CB[7]‒PEG) has been shown to stabilize insulin formulations by reducing aggregation propensity. Yet prolonged

Indexed as

Diabetes mellitusHypoglycemiaInsulin aggregationN-terminal acid-modified insulinSelective N-Terminal modificationSubcutaneous administrationSubcutaneous depotSupramolecular PEGylation

Identifiers

PMID37250160
PMCPMC10213764
OpenAlexW4315618924

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.