Evidence map›Paper›PMID 37250102›Full record

ArticleCurrent ophthalmology reports2022

Outcomes of Pythium keratitis: a meta-analysis of individual patient data.

Binh Cao, Vishnu Teja Gonugunta, Naveen Radhakrishnan, Prajna Lalitha, Bharat Gurnani, Kirandeep Kaur, Geetha Iyer, Shweta Agarwal, Bhaskar Srinivasan, Jeremy D Keenan and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current ophthalmology reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 9 citations in OpenAlex.

  1. Immune Camouflage inClinical ophthalmology (Auckland, N.Z.) · 2025
    Article
  2. Renaissance of an Emerging Pathogen-Clinical ophthalmology (Auckland, N.Z.) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Binh CaoFrancis I Proctor Foundation, University of California, San Francisco, USA.
Vishnu Teja GonuguntaDepartment of Cornea and Refractive Surgery, Aravind Eye Hospital Madurai, India.
Naveen RadhakrishnanDepartment of Cornea and Refractive Surgery, Aravind Eye Hospital Madurai, India.
Prajna LalithaDepartment of Ocular Microbiology, Aravind Eye Hospital Madurai, India.
Bharat GurnaniDr. Om Parkash Eye Institute, Amritsar, India.
Kirandeep KaurDr. Om Parkash Eye Institute, Amritsar, India.
Geetha IyerC J Shah Cornea Services, Dr G Sitalakshmi Memorial Clinic for Ocular Surface Disorders, Sankara Nethralaya, Chennai, India.
Shweta AgarwalC J Shah Cornea Services, Dr G Sitalakshmi Memorial Clinic for Ocular Surface Disorders, Sankara Nethralaya, Chennai, India.
Bhaskar SrinivasanC J Shah Cornea Services, Dr G Sitalakshmi Memorial Clinic for Ocular Surface Disorders, Sankara Nethralaya, Chennai, India.
Jeremy D KeenanFrancis I Proctor Foundation, University of California, San Francisco, USA.
N Venkatesh PrajnaDepartment of Cornea and Refractive Surgery, Aravind Eye Hospital Madurai, India.
Aravind Eye Hospital · INSankara Nethralaya · INUniversity of California, San Francisco · US

Funding

University of California Launching Future Leaders in Global Health Research Training ProgramD43TW009343 · FIC · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CRAIG R COHEN, Sung-Jae Lee · 2017 to 2026
$14.7M
FIC NIH HHS D43 TW009343
6 · The paper itself

Abstract

Background: Pythium keratitis is a difficult-to-treat corneal infection. Methods: A meta-analysis of individual patient data from observational studies of Pythium keratitis was performed. The outcomes of interest were therapeutic penetrating keratoplasty (TPK) and globe removal (evisceration, enucleation, or exenteration); the main exposures were linezolid and azithromycin use. Findings: Of 46 eligible articles, individual patient data were available for 306 eyes (34 studies). Pythium keratitis was associated with high rates of TPK (80%, 95%CI 70-87%) and globe removal (25%, 95%CI 13-43). In multivariable models adjusting for age and country, fewer TPKs were performed in patients treated with azithromycin (RR=0.80, 95%CI 0.67-0.96; Conclusions: Studies of Pythium keratitis reported high rates of TPK and globe removal. Use of azithromycin and linezolid was associated with a lower rate of TPK. While promising, these results should be interpreted with caution given the biases inherent to observational studies.

Indexed as

azithromycincorneal ulcerlinezolidpenetrating keratoplastypythiosisPythiumsystematic review

Identifiers

PMID37250102
PMCPMC10211475
OpenAlexW4308640905

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.