ArticleJournal of the American Chemical Society2023
Dual Nickel/Photoredox-Catalyzed Asymmetric Carbosulfonylation of Alkenes.
Article in Journal of the American Chemical Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Remote 1,5-Difunctionalization of Alkenes via a Sulfinyl-Smiles Rearrangement and Vinylcyclopropane Ring-Opening Cascade.JACS Au · 2026Article
- Photocatalytic multicomponent alkene dicarbofunctionalizationChemical science · 2026Article
- Stereoselective vicinal C(sp³)-C bond formation via metallaphotoredox 1,2-difunctionalization of internal alkenes.Nature communications · 2026Article
- Vinyl cyclopropanes as a unifying platform for enantioselective remote difunctionalization of alkenes.Nature communications · 2025Article
- Biomimetic 1,2-amino migration via photoredox catalysis.Nature chemistry · 2025Article
- Nickel catalyzed C-N coupling of haloarenes with BNature communications · 2025Article
- Enantioselective reductive cross-couplings to forge C(spNature communications · 2025Article
- Enantioselective construction of C-B axially chiral alkenylborons by nickel-catalyzed radical relayed reductive coupling.Nature communications · 2024Article
- General Alkene 1,2-Journal of the American Chemical Society · 2024Article
- Carbosulfonylation of Alkynes: A Direct Conversion of sp-C to spOrganic letters · 2024Article
- Red-light-mediated copper-catalyzed photoredox catalysis promotes regioselectivity switch in the difunctionalization of alkenes.Nature communications · 2024Article
- Ni-catalyzed enantioconvergent deoxygenative reductive cross-coupling of unactivated alkyl alcohols and aryl bromides.Nature communications · 2024Article
- Strain-enabled radical spirocyclization cascades: rapid access to spirocyclobutyl lactones and - lactams.Chemical science · 2024Article
- Recent advances in catalytic asymmetric synthesis.Frontiers in chemistry · 2024Review
- Nickel-catalysed enantioselective alkene dicarbofunctionalization enabled by photochemical aliphatic C-H bond activation.Nature catalysis · 2024Article
- Nickel/photoredox dual catalyzed arylalkylation of nonactivated alkenes.Nature communications · 2023Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An asymmetric three-component carbosulfonylation of alkenes is presented here. The reaction, involving the simultaneous formation of a C-C and a C-S bond across the π-system, uses a dual nickel/photoredox catalytic system to produce both β-aryl and β-alkenyl sulfones in high yields and with excellent levels of stereocontrol (up to 99:1 er). This protocol exhibits a broad substrate scope and excellent functional group tolerance and its synthetic potential has been demonstrated by successful applications toward pharmacologically relevant molecules. A broad array of control experiments supports the involvement of a secondary alkyl radical intermediate generated through radical addition of a sulfonyl radical to the double bond. Moreover, stoichiometric and cross-over experiments further suggest an underlying Ni(0)/Ni(I)/Ni(III) pathway operative in these transformations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.