ArticlePhysical and engineering sciences in medicine2023
Being certain about uncertainties: a robust evaluation method for high-dose-rate prostate brachytherapy treatment plans including the combination of uncertainties.
Article in Physical and engineering sciences in medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed, 14 citations in OpenAlex.
- Robust optimization of catheter positions and dwell times for HDR prostate brachytherapy.Medical physics · 2026Article
- A constraint-normalized robustness index for HDR brachytherapy.Medical physics · 2026Article
- Definition of a framework for volumetric modulated arc therapy plan quality assessment with integration of dose-, complexity-, and robustness metrics.Physics and imaging in radiation oncology · 2024Article
- A robust evaluation of 49 high-dose-rate prostate brachytherapy treatment plans including all major uncertainties.Journal of applied clinical medical physics · 2024Article
- Overview of treatment plan quality in a high dose rate prostate brachytherapy workflow.BrachytherapyArticle
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In high-dose-rate (HDR) prostate brachytherapy the combined effect of uncertainties cause a range of possible dose distributions deviating from the nominal plan, and which are not considered during treatment plan evaluation. This could lead to dosimetric misses for critical structures and overdosing of organs at risk. A robust evaluation method to assess the combination of uncertainties during plan evaluation is presented and demonstrated on one HDR prostate ultrasound treatment plan retrospectively. A range of uncertainty scenarios are simulated by changing six parameters in the nominal plan and calculating the corresponding dose distribution. Two methods are employed to change the parameters, a probabilistic approach using random number sampling to evaluate the likelihood of variation in dose distributions, and a combination of the most extreme possible values to access the worst-case dosimetric outcomes. One thousand probabilistic scenarios were run on the single treatment plan with 43.2% of scenarios passing seven of the eight clinical objectives. The prostate D
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.