Evidence map›Paper›PMID 37249803›Full record

ReviewJournal of medical toxicology : official journal of the American College of Medical Toxicology2023

Pharmaceutical Purchasing: a Review of the Landscape and Implications for Antidotal Therapies.

Andrew Troger, Michele M Burns

Open access · greenAbstract readReview
In one paragraph

Review in Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.9field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Trends in Shortages of Lead Chelators From 2001 to 2022.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2024
    Article
  2. Review
  3. Drug Shortages Negatively Impact Health Systems and Bedside Patient Care.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Andrew TrogerHarvard Medical Toxicology Fellowship, Boston, MA, USA. andrew.troger@childrens.harvard.edu.ORCID 0000-0003-2630-0311
Michele M BurnsHarvard Medical Toxicology Fellowship, Boston, MA, USA.
Boston Children's Hospital · USCambridge Health Alliance · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The management of the poisoned patient often requires the utilization of uncommonly used pharmaceutical interventions. These interventions can be associated with significant costs to both the patient and treating institution. Pharmaceutical supply shortages and issues with accessibility of antidotal therapies complicate the management of many toxic exposures. These challenges are an inherent property of the pharmaceutical purchasing infrastructure in the United States, which is a complicated network of public and private intra-institutional agreements. The cost and availability of any given therapy is dependent on the individual contracting agreements between the treating institution, payer, pharmacy benefit manager, manufacturer or wholesaler, and in some cases a specialty pharmacy. Small or remote hospitals may experience greater challenges related to insufficient patient volume to achieve predicable prescribing patterns of rare and expensive medications, necessitating consignment purchasing arrangements. Although pharmaceutical costs are the focus of recent legislative attention, these reforms are not expected to significantly alter the cost or availability of antidotal therapies.

Indexed as

PharmaciesPharmacyAntidotesDrug CostsHumansPharmaceutical PreparationsUnited StatesAntidotesPharmaceutical PreparationsAntidotesDrug pricesDrug purchasingDrug shortagesPharmaceuticals

Identifiers

PMID37249803
PMCPMC10293135
OpenAlexW4378745233

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.