Evidence map›Paper›PMID 37249732›Full record

ArticleJournal of muscle research and cell motility2023

Characteristics of the right atrial and right ventricular contractility in a model of monocrotaline-induced pulmonary arterial hypertension.

Oksana P Gerzen, Ruslan V Lisin, Alexander A Balakin, Elena A Mukhlynina, Daniil A Kuznetsov, Larisa V Nikitina, Yuri L Protsenko

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of muscle research and cell motility, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Cardiovascular system characteristics in HIV/AIDS patients with talaromycosis.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas · 2026
    Article
  2. Right ventricle remodelling: fromJournal of molecular and cellular cardiology plus · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Oksana P GerzenInstitute of Immunology and Physiology, Ural Branch of Russian Academy of Sciences, 106 Pervomayskaya st, Yekaterinburg, 620049, Russian Federation.
Ruslan V LisinInstitute of Immunology and Physiology, Ural Branch of Russian Academy of Sciences, 106 Pervomayskaya st, Yekaterinburg, 620049, Russian Federation.
Alexander A BalakinInstitute of Immunology and Physiology, Ural Branch of Russian Academy of Sciences, 106 Pervomayskaya st, Yekaterinburg, 620049, Russian Federation. balakin_a_a@mail.ru.
Elena A MukhlyninaInstitute of Immunology and Physiology, Ural Branch of Russian Academy of Sciences, 106 Pervomayskaya st, Yekaterinburg, 620049, Russian Federation.
Daniil A KuznetsovInstitute of Immunology and Physiology, Ural Branch of Russian Academy of Sciences, 106 Pervomayskaya st, Yekaterinburg, 620049, Russian Federation.
Larisa V NikitinaInstitute of Immunology and Physiology, Ural Branch of Russian Academy of Sciences, 106 Pervomayskaya st, Yekaterinburg, 620049, Russian Federation.
Yuri L ProtsenkoInstitute of Immunology and Physiology, Ural Branch of Russian Academy of Sciences, 106 Pervomayskaya st, Yekaterinburg, 620049, Russian Federation.
Institute of Immunology and Physiology · RUUral Branch of the Russian Academy of Sciences · RU

Funding

Russian Science Foundation 21-15-00169
6 · The paper itself

Abstract

Pulmonary arterial hypertension (PAH) leads to changes in the pump function of the heart and causes right-sided myocardial hypertrophy and heart failure. This study was the first to compare the contractile characteristics of the multicellular myocardial preparations of the right atrium (RA) and right ventricle (RV) of male rats from the control group (CON) and the group with monocrotaline (MCT)-induced hypertrophy at the molecular and multicellular levels. In both RA and RV in MCT-treated rats, the fraction of motile filaments and the maximum sliding velocity of actin and reconstituted thin filaments over myosin decreased, and the ratio of α-/β-myosin heavy chains (MHC) shifted towards β-MHC. In the RA strips and RV trabeculae, the maximum shortening velocity, the extent of muscle shortening, the amplitude of isometric stress, the amount of work decreased. PAH leads to a greater drop in right atrial contractility than that of the ventricle.

Indexed as

Atrial FibrillationHypertension, PulmonaryPulmonary Arterial HypertensionAnimalsDisease Models, AnimalHeart AtriaHeart VentriclesHypertrophy, Right VentricularMaleMonocrotalineRatsMonocrotalineMechanical characteristicsMonocrotalineMyosinPulmonary arterial hypertensionRight atriumRight ventricle

Identifiers

PMID37249732
OpenAlexW4378746250

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.