Evidence map›Paper›PMID 37249658›Full record

Trial reportUrolithiasis2023

A randomized, double-blind, placebo-controlled clinical trial of the use of hydroxycitric acid adjuvant to shock wave lithotripsy therapy in patients with calcium stones. Stone fragmentation results.

María Del Carmen Cano García, Rocío Caballero Cobos, Álvaro Vadillo Bohorquez, Patricia Molina Díaz, Yaiza Yañez Castillo, Carlos Reina Ruiz, Francisco Gutiérrez-Tejero, Miguel Ángel Arrabal Polo, Miguel Arrabal Martín

Registry-linked trialOpen access · greenAbstract readRandomized Controlled TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Urolithiasis, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05525130 (Experimental Study of the Administration of a Food Supplement Containing Hydroxycitric Acid Versus Placebo in Patients With Oxalate and Calcium Phosphate Lithiasis in Whom Extracorporeal Shock Wave Lithotripsy is Indicated.), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05525130 nacompletednot on this map

Experimental Study of the Administration of a Food Supplement Containing Hydroxycitric Acid Versus Placebo in Patients With Oxalate and Calcium Phosphate Lithiasis in Whom Extracorporeal Shock Wave Lithotripsy is Indicated.

TypeinterventionalSponsorArafarma Group, S.A.Ran2020 to 2022Enrolled81ConditionsLithiasis, NephrolithiasisArmsFood supplement, Placebo
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

María Del Carmen Cano GarcíaIBS Granada, Granada, Spain.
Rocío Caballero CobosRegional University Hospital, Málaga, Spain.
Álvaro Vadillo BohorquezVirgen del Valme University Hospital, Seville, Spain.
Patricia Molina DíazRegional University Hospital, Málaga, Spain.
Yaiza Yañez CastilloSan Cecilio University Hospital, Avda. de la Investigación, S/N, 18016, Granada, Spain.
Carlos Reina RuizVirgen del Valme University Hospital, Seville, Spain.
Francisco Gutiérrez-TejeroSan Cecilio University Hospital, Avda. de la Investigación, S/N, 18016, Granada, Spain.
Miguel Ángel Arrabal PoloIBS Granada, Granada, Spain. arrabalp29@gmail.com.
Miguel Arrabal MartínIBS Granada, Granada, Spain.
Instituto de Investigación Biosanitaria de Granada · ESHospital Regional Universitario de Málaga · ESHospital Universitario de Valme · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Our objective was to improve the results of extracorporeal shock waves lithotripsy using hydroxycitric acid (HCA) like adjuvant therapy. Double blind randomized clinical trial using hydroxycitric acid versus placebo (ID NCT05525130). Multicenter study of adjuvant exposure to a food supplement with hydroxycitric acid (HCA), vs. placebo in patients with calcium oxalate and calcium phosphate lithiasis with indication for extracorporeal shock wave lithotripsy (ESWL). 81 patients were included in the study to compare the effect of HCA versus placebo. Stone fragmentation, the main efficacy variable. Other variables analyzed were stone size, Hounsfield Unit Stone and tolerability. Statistical study with SPSS, statistical significance p ≤ 0.05. Eighty-one patients were included, 40 in the intervention group with HCA and 41 in the control group with placebo. The average stone area was 174,36 mm

Indexed as

Kidney CalculiLithotripsyCalciumCitratesHumansTreatment OutcomeCalciumCitrateshydroxycitric acidCalcium lithiasisExtracorporeal lithotripsyHydroxycitric acid

Identifiers

PMID37249658
PMCPMC10228427
OpenAlexW4378745828

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.