Evidence map›Paper›PMID 37249618›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2023

In vivo evaluation of a novel

Xuefeng Yan, Fabrice G Siméon, Jeih-San Liow, Cheryl L Morse, Jose A Montero Santamaria, Madeline Jenkins, Lester S Manly, Maia Van Buskirk, Sami S Zoghbi, Victor W Pike and 2 more

Open access · hybridAbstract read
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Preclinical characterization of [Acta pharmacologica Sinica · 2025
    Article
  2. Radiopharmaceuticals and their applications in medicine.Signal transduction and targeted therapy · 2025
    Review
  3. Discovery and evaluation of a novelActa pharmaceutica Sinica. B · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Xuefeng YanMolecular Imaging Branch, National Institute of Mental Health, NIH, 10 Center Drive, Bethesda, MD, 20892, USA. xuefeng.yan@nih.gov.ORCID 0000-0002-9803-5222
Fabrice G SiméonMolecular Imaging Branch, National Institute of Mental Health, NIH, 10 Center Drive, Bethesda, MD, 20892, USA.ORCID 0000-0003-1337-5832
Jeih-San LiowMolecular Imaging Branch, National Institute of Mental Health, NIH, 10 Center Drive, Bethesda, MD, 20892, USA.ORCID 0000-0002-7878-1076
Cheryl L MorseMolecular Imaging Branch, National Institute of Mental Health, NIH, 10 Center Drive, Bethesda, MD, 20892, USA.
Jose A Montero SantamariaMolecular Imaging Branch, National Institute of Mental Health, NIH, 10 Center Drive, Bethesda, MD, 20892, USA.ORCID 0000-0003-0069-7445
Madeline JenkinsMolecular Imaging Branch, National Institute of Mental Health, NIH, 10 Center Drive, Bethesda, MD, 20892, USA.
Lester S ManlyMolecular Imaging Branch, National Institute of Mental Health, NIH, 10 Center Drive, Bethesda, MD, 20892, USA.ORCID 0000-0003-2047-090X
Maia Van BuskirkMolecular Imaging Branch, National Institute of Mental Health, NIH, 10 Center Drive, Bethesda, MD, 20892, USA.
Sami S ZoghbiMolecular Imaging Branch, National Institute of Mental Health, NIH, 10 Center Drive, Bethesda, MD, 20892, USA.ORCID 0000-0001-5613-8314
Victor W PikeMolecular Imaging Branch, National Institute of Mental Health, NIH, 10 Center Drive, Bethesda, MD, 20892, USA.ORCID 0000-0001-9032-2553
Robert B InnisMolecular Imaging Branch, National Institute of Mental Health, NIH, 10 Center Drive, Bethesda, MD, 20892, USA.ORCID 0000-0003-1238-7209
Paolo Zanotti-FregonaraMolecular Imaging Branch, National Institute of Mental Health, NIH, 10 Center Drive, Bethesda, MD, 20892, USA.
National Institute of Mental Health · US

Funding

PET Radiopharmaceutical SciencesZIAMH002793 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI PIKE, VICTOR W · 2009 to 2025
$69.8M
Clinical Evaluation of PET RadiotracersZIAMH002852 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI INNIS, ROBERT · 2009 to 2025
$48.6M
Translational Evaluation Of PET RadiotracersZIAMH002795 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI INNIS, ROBERT · 2009 to 2025
$32.0M
PET Radiopharmaceutical SciencesZ01MH002793 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI PIKE, VICTOR W · 2002 to 2008
$7.4M
Intramural NIH HHS Z01 MH002793Intramural NIH HHS ZIA MH002793NIMH NIH HHS ZIA-MH002793NIMH NIH HHS ZIA-MH002852
6 · The paper itself

Abstract

purpose[

methodsPositron emission tomography (PET) imaging was performed in monkey brain (n = 3) at baseline and after pre-blockade with the TSPO ligands PK11195 and PBR28. TSPO binding was calculated as total distribution volume corrected for free parent fraction in plasma (V

resultsAfter [

conclusionThe results demonstrate that [

Indexed as

BrainReceptors, GABAAnimalsCarrier ProteinsHumansMicePositron-Emission TomographyProtein BindingRadiopharmaceuticalsCarrier ProteinsRadiopharmaceuticalsReceptors, GABATSPO protein, human[18F]SF51BrainMonkeyPETTSPO

Identifiers

PMID37249618
PMCPMC10382351
OpenAlexW4378745305

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.