Evidence map›Paper›PMID 37249283›Full record

SynthesisImmunity, inflammation and disease2023

Biological research on the occurrence and development of multiple myeloma and its treatment.

Yue Wu, Xiangjun Shi, Xinchen Yao, Xinru Du

Abstract readSystematic Review
In one paragraph

Synthesis in Immunity, inflammation and disease, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yue WuDepartment of Orthopaedics, Beijing Chao-Yang Hospital, Beijing, China.
Xiangjun ShiDepartment of Orthopaedics, Beijing Chao-Yang Hospital, Beijing, China.
Xinchen YaoDepartment of Orthopaedics, Beijing Chao-Yang Hospital, Beijing, China.
Xinru DuDepartment of Orthopaedics, Beijing Chao-Yang Hospital, Beijing, China.ORCID 0000-0002-2295-0934

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionTo review the pathogenesis and treatment of multiple myeloma (MM). MM is a hematological malignancy with abnormal plasma cell proliferation in bone marrow. Due to the emergence of drug resistance, MM is still an incurable malignancy, which requires further exploration of pathogenesis and effective therapeutic targets.

methodsIn this paper, the method of literature review is adopted to obtain the information about MM. Based on the literature, comprehensive and systematic review is made.

resultsMM is a complex pathophysiological process with great heterogeneity, mainly reflected in genomic instability and bone marrow microenvironment. At present, the treatment of MM has made great progress, proteasome inhibitors and immunomodulatory drugs are widely used in clinic. Allogeneic stem cell transplantation may be the only promising cure for MM, and its high transplant-related mortality limits its clinical application.

conclusionsThe future of MM treatment lies in the development of more targeted therapies, novel immunotherapies, and a better understanding of the disease's molecular and genetic basis.

Indexed as

Hematopoietic Stem Cell TransplantationMultiple MyelomaHumansImmunotherapyTumor Microenvironmentbiological researchhematopoietic stem cell transplantationimmunomodulatory drugsimmunotherapymultiple myelomaproteasome inhibitor

Identifiers

PMID37249283
PMCPMC10165958

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.