Evidence map›Paper›PMID 37249218›Full record

ArticleeLife2023

The Uso1 globular head interacts with SNAREs to maintain viability even in the absence of the coiled-coil domain.

Ignacio Bravo-Plaza, Victor G Tagua, Herbert N Arst, Ana Alonso, Mario Pinar, Begoña Monterroso, Antonio Galindo, Miguel A Peñalva

Open access · goldAbstract read
In one paragraph

Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
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  6. A bird's-eye view of the endoplasmic reticulum in filamentous fungi.Microbiology and molecular biology reviews : MMBR · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Ignacio Bravo-PlazaDepartment of Cellular and Molecular Biology, CSIC Centro de Investigaciones Biológicas, Madrid, Spain.ORCID 0000-0003-0934-9084
Victor G TaguaInstituto de Tecnologías Biomédicas, Hospital Universitario Nuestra Señora de Candelaria, Santa Cruz de Tenerife, Spain.ORCID 0000-0003-1494-6895
Herbert N ArstDepartment of Infectious Diseases, Faculty of Medicine, Flowers Building, Imperial College, London, United Kingdom.
Ana AlonsoDepartment of Cellular and Molecular Biology, CSIC Centro de Investigaciones Biológicas, Madrid, Spain.
Mario PinarDepartment of Cellular and Molecular Biology, CSIC Centro de Investigaciones Biológicas, Madrid, Spain.ORCID 0000-0002-2415-8721
Begoña MonterrosoDepartment of Structural and Chemical Biology, CSIC Centro de Investigaciones Biológicas, Madrid, Spain.ORCID 0000-0003-2538-084X
Antonio GalindoDivision of Cell Biology, MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, United Kingdom.
Miguel A PeñalvaDepartment of Cellular and Molecular Biology, CSIC Centro de Investigaciones Biológicas, Madrid, Spain.ORCID 0000-0002-3102-2806
Centro de Investigaciones Biológicas Margarita Salas · ESHospital Universitario Nuestra Señora de Candelaria · ESMRC Laboratory of Molecular Biology · GB

Funding

Medical Research Council MC_U105178783
6 · The paper itself

Abstract

Uso1/p115 and RAB1 tether ER-derived vesicles to the Golgi. Uso1/p115 contains a globular-head-domain (GHD), a coiled-coil (CC) mediating dimerization/tethering, and a C-terminal region (CTR) interacting with golgins. Uso1/p115 is recruited to vesicles by RAB1. Genetic studies placed Uso1 paradoxically acting upstream of, or in conjunction with RAB1 (Sapperstein et al., 1996). We selected two missense mutations in

Indexed as

SNARE ProteinsVesicular Transport ProteinsBranchio-Oto-Renal SyndromeGolgi ApparatusProtein DomainsSNARE ProteinsVesicular Transport ProteinsAspergillus nidulanscell biologyRAB1S. cerevisiaeSNAREsS. pombetethering

Identifiers

PMID37249218
PMCPMC10275640
OpenAlexW4378746447

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.