ArticleeLife2023
Target cell-specific synaptic dynamics of excitatory to inhibitory neuron connections in supragranular layers of human neocortex.
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Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
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Who cites it
24 citing papers in PubMed, 33 citations in OpenAlex.
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Authors and funding
37 authors at 3 institutions in 2 countries.
Mean-Hwan KimAllen Institute for Brain Science, Seattle, United States.ORCID 0000-0002-8065-4631
Cristina RadaelliAllen Institute for Brain Science, Seattle, United States.
Elliot R ThomsenAllen Institute for Brain Science, Seattle, United States.
Deja MonetAllen Institute for Brain Science, Seattle, United States.
Thomas ChartrandAllen Institute for Brain Science, Seattle, United States.ORCID 0000-0002-7093-8681
Nikolas L JorstadAllen Institute for Brain Science, Seattle, United States.
Joseph T MahoneyAllen Institute for Brain Science, Seattle, United States.ORCID 0000-0003-1374-3893
Michael J TaorminaAllen Institute for Brain Science, Seattle, United States.
Brian LongAllen Institute for Brain Science, Seattle, United States.
Katherine BakerAllen Institute for Brain Science, Seattle, United States.
Trygve E BakkenAllen Institute for Brain Science, Seattle, United States.ORCID 0000-0003-3373-7386
Luke CampagnolaAllen Institute for Brain Science, Seattle, United States.
Tamara CasperAllen Institute for Brain Science, Seattle, United States.
Michael ClarkAllen Institute for Brain Science, Seattle, United States.
Nick DeeAllen Institute for Brain Science, Seattle, United States.
Florence D'OraziAllen Institute for Brain Science, Seattle, United States.
Clare GamlinAllen Institute for Brain Science, Seattle, United States.
Brian E KalmbachAllen Institute for Brain Science, Seattle, United States.
Sara KebedeAllen Institute for Brain Science, Seattle, United States.
Brian R LeeAllen Institute for Brain Science, Seattle, United States.ORCID 0000-0002-3210-5638
Lindsay NgAllen Institute for Brain Science, Seattle, United States.
Jessica TrinhAllen Institute for Brain Science, Seattle, United States.
Charles CobbsSwedish Neuroscience Institute, Seattle, United States.
Ryder P GwinnSwedish Neuroscience Institute, Seattle, United States.
C Dirk KeeneDepartment of Laboratory Medicine & Pathology, School of Medicine, University of Washington, Seattle, United States.ORCID 0000-0002-5291-1469
Andrew L KoDepartment of Neurological Surgery, School of Medicine, University of Washington, Seattle, United States.
Jeffrey G OjemannDepartment of Neurological Surgery, School of Medicine, University of Washington, Seattle, United States.
Daniel L SilbergeldDepartment of Neurological Surgery, School of Medicine, University of Washington, Seattle, United States.
Staci A SorensenAllen Institute for Brain Science, Seattle, United States.
Jim BergAllen Institute for Brain Science, Seattle, United States.
Kimberly A SmithAllen Institute for Brain Science, Seattle, United States.
Philip R NicovichAllen Institute for Brain Science, Seattle, United States.
Tim JarskyAllen Institute for Brain Science, Seattle, United States.ORCID 0000-0002-4399-539X
Hongkui ZengAllen Institute for Brain Science, Seattle, United States.ORCID 0000-0002-0326-5878
Jonathan T TingAllen Institute for Brain Science, Seattle, United States.
Boaz P LeviAllen Institute for Brain Science, Seattle, United States.
Ed LeinAllen Institute for Brain Science, Seattle, United States.
Allen Institute for Brain Science · USUniversity of Washington · USNeuroscience Institute · IT
Funding
University of Washington Alzheimer's Disease Research CenterP30AG066509 · NIA · UNIVERSITY OF WASHINGTON · PI SUMAN JAYADEV · 2020 to 2026
$29.0MDevelopment of tools for cell-type specific labeling of human and mouse neocortical neuronsRF1MH114126 · NIMH · ALLEN INSTITUTE · PI LEIN, ED, LEVI, BOAZ PIRIE · 2017 to 2017
$4.5MMozak: Creating an Expert Community to accelerate neuronal reconstruction at scaleR01MH116247 · NIMH · UNIVERSITY OF WASHINGTON · PI POPOVIC, ZORAN · 2018 to 2022
$3.1MNIA NIH HHS P30 AG066509NIH HHS BRAIN Initiative RF1MH114126NIMH NIH HHS R01 MH116247NIMH NIH HHS RF1 MH114126
Abstract
Rodent studies have demonstrated that synaptic dynamics from excitatory to inhibitory neuron types are often dependent on the target cell type. However, these target cell-specific properties have not been well investigated in human cortex, where there are major technical challenges in reliably obtaining healthy tissue, conducting multiple patch-clamp recordings on inhibitory cell types, and identifying those cell types. Here, we take advantage of newly developed methods for human neurosurgical tissue analysis with multiple patch-clamp recordings,
Indexed as
NeocortexHumansIn Situ Hybridization, FluorescenceInterneuronsNeuronsProspective StudiesPyramidal CellsSynapsesSynaptic Transmissioncerebral cortexhumanneurosciencesynaptic connection
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.