Evidence map›Paper›PMID 37248794›Full record

ReviewWiley interdisciplinary reviews. Nanomedicine and nanobiotechnology

Nanotechnology-empowered therapeutics targeting neurodegenerative diseases.

Zhiren Wang, Karina Marie Gonzalez, Leyla Estrella Cordova, Jianqin Lu

Abstract readReview
In one paragraph

Review in Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Zhiren WangSkaggs Pharmaceutical Sciences Center, Department of Pharmacology & Toxicology, R. Ken Coit College of Pharmacy, The University of Arizona, Tucson, Arizona, USA.ORCID 0000-0002-2016-0517
Karina Marie GonzalezSkaggs Pharmaceutical Sciences Center, Department of Pharmacology & Toxicology, R. Ken Coit College of Pharmacy, The University of Arizona, Tucson, Arizona, USA.
Leyla Estrella CordovaSkaggs Pharmaceutical Sciences Center, Department of Pharmacology & Toxicology, R. Ken Coit College of Pharmacy, The University of Arizona, Tucson, Arizona, USA.
Jianqin LuSkaggs Pharmaceutical Sciences Center, Department of Pharmacology & Toxicology, R. Ken Coit College of Pharmacy, The University of Arizona, Tucson, Arizona, USA.ORCID 0000-0002-5877-619X

Funding

SOUTHWEST ENVIRONMENTAL HEALTH SCIENCES CENTERP30ES006694 · NIEHS · UNIVERSITY OF ARIZONA · PI DEAN BILLHEIMER · 1994 to 2026
$36.7M
A fortified lipid bilayer platform for improved drug packaging and therapeutic deliveryR35GM147002 · NIGMS · UNIVERSITY OF ARIZONA · PI Jianqin Lu · 2022 to 2026
$1.9M
A Phospholipid-Derived Nanotherapeutic Platform for Improved Colorectal Cancer ImmunochemotherapyR01CA272487 · NCI · UNIVERSITY OF ARIZONA · PI Jianqin Lu · 2023 to 2026
$1.4M
UA Environmental Health Transformative Research Undergrad Experience(EH TRUE)R25ES025494 · NIEHS · UNIVERSITY OF ARIZONA · PI CHEN, YIN · 2015 to 2024
$1.1M
NCI NIH HHS R01 CA272487NIEHS NIH HHS P30 ES006694NIEHS NIH HHS R25 ES025494NIGMS NIH HHS R35 GM147002
6 · The paper itself

Abstract

Neurodegenerative diseases are posing pressing health issues due to the high prevalence among aging populations in the 21st century. They are evidenced by the progressive loss of neuronal function, often associated with neuronal necrosis and many related devastating complications. Nevertheless, effective therapeutical strategies to treat neurodegenerative diseases remain a tremendous challenge due to the multisystemic nature and limited drug delivery to the central nervous system. As a result, there is a pressing need to develop effective alternative therapeutics to manage the progression of neurodegenerative diseases. By utilizing the functional reconstructive materials and technologies with specific targeting ability at the nanoscale level, nanotechnology-empowered medicines can transform the therapeutic paradigms of neurodegenerative diseases with minimal systemic side effects. This review outlines the current applications and progresses of the nanotechnology-enabled drug delivery systems to enhance the therapeutic efficacy in treating neurodegenerative diseases. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Neurological Disease Therapeutic Approaches and Drug Discovery > Emerging Technologies.

Indexed as

NanoparticlesNeurodegenerative DiseasesBlood-Brain BarrierDrug Delivery SystemsHumansNanomedicineNanotechnologyblood brain barriercentral nervous systemdrug deliverynanotechnologyneurodegenerative diseases

Identifiers

PMID37248794
PMCPMC10525015

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.