Evidence map›Paper›PMID 37248777›Full record

ArticleAdvanced healthcare materials2023

Microgels as Platforms for Antibody-Mediated Cytokine Scavenging.

Sarah Boesveld, Yonca Kittel, Yizhao Luo, Alexander Jans, Burak Oezcifci, Matthias Bartneck, Christian Preisinger, Dirk Rommel, Tamás Haraszti, Silvia P Centeno and 5 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 9 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 2 countries.

Sarah BoesveldDepartment of Internal Medicine III, University Hospital, RWTH Aachen University, Pauwelsstraße 30, 52074, Aachen, Germany.
Yonca KittelDWI-Leibniz Institute for Interactive Materials, RWTH Aachen University, Forckenbeckstraße 50, 52074, Aachen, Germany.
Yizhao LuoDepartment of Internal Medicine III, University Hospital, RWTH Aachen University, Pauwelsstraße 30, 52074, Aachen, Germany.
Alexander JansDepartment of Internal Medicine III, University Hospital, RWTH Aachen University, Pauwelsstraße 30, 52074, Aachen, Germany.
Burak OezcifciDWI-Leibniz Institute for Interactive Materials, RWTH Aachen University, Forckenbeckstraße 50, 52074, Aachen, Germany.
Matthias BartneckDepartment of Internal Medicine III, University Hospital, RWTH Aachen University, Pauwelsstraße 30, 52074, Aachen, Germany.
Christian PreisingerProteomics Facility, Interdisciplinary Centre for Clinical Research (IZKF), Medical School, RWTH Aachen University, Pauwelsstraße 30, 52074, Aachen, Germany.
Dirk RommelDWI-Leibniz Institute for Interactive Materials, RWTH Aachen University, Forckenbeckstraße 50, 52074, Aachen, Germany.
Tamás HarasztiDWI-Leibniz Institute for Interactive Materials, RWTH Aachen University, Forckenbeckstraße 50, 52074, Aachen, Germany.
Silvia P CentenoDWI-Leibniz Institute for Interactive Materials, RWTH Aachen University, Forckenbeckstraße 50, 52074, Aachen, Germany.
Arnold J BoersmaDWI-Leibniz Institute for Interactive Materials, RWTH Aachen University, Forckenbeckstraße 50, 52074, Aachen, Germany.
Laura De LaporteDWI-Leibniz Institute for Interactive Materials, RWTH Aachen University, Forckenbeckstraße 50, 52074, Aachen, Germany.ORCID 0000-0002-9438-0977
Christian TrautweinDepartment of Internal Medicine III, University Hospital, RWTH Aachen University, Pauwelsstraße 30, 52074, Aachen, Germany.
Alexander J C KuehneInstitute of Organic and Macromolecular Chemistry, Ulm University, Albert-Einstein-Allee 11, 89081, Ulm, Germany.ORCID 0000-0003-0142-8001
Pavel StrnadDepartment of Internal Medicine III, University Hospital, RWTH Aachen University, Pauwelsstraße 30, 52074, Aachen, Germany.ORCID 0000-0002-7122-6379
RWTH Aachen University · DEDWI – Leibniz Institute for Interactive Materials · DEUniversität Ulm · DEUtrecht University · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Therapeutic antibodies are the key treatment option for various cytokine-mediated diseases, such as rheumatoid arthritis, psoriasis, and inflammatory bowel disease. However, systemic injection of these antibodies can cause side effects and suppress the immune system. Moreover, clearance of therapeutic antibodies from the blood is limiting their efficacy. Here, water-swollen microgels are produced with a size of 25 µm using droplet-based microfluidics. The microgels are functionalized with TNFα antibodies to locally scavenge the pro-inflammatory cytokine TNFα. Homogeneous distribution of TNFα-antibodies is shown throughout the microgel network and demonstrates specific antibody-antigen binding using confocal microscopy and FLIM-FRET measurements. Due to the large internal accessibility of the microgel network, its capacity to bind TNFα is extremely high. At a TNFα concentration of 2.5 µg mL

Indexed as

MicrogelsAntibodiesCytokinesHT29 CellsHumansTumor Necrosis Factor-alphaAntibodiesCytokinesMicrogelsTumor Necrosis Factor-alphaantibodyautoimmune diseaseinflammationlocal therapymicrogelsTNFα scavenging

Identifiers

PMID37248777
PMCPMC11469277
OpenAlexW4378745927

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.