ArticleCNS neuroscience & therapeutics2023
Paraventricular nucleus-central amygdala oxytocinergic projection modulates pain-related anxiety-like behaviors in mice.
Article in CNS neuroscience & therapeutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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34 citing papers in PubMed, 46 citations in OpenAlex.
- Article
- Progress in pain mechanisms and management.Signal transduction and targeted therapy · 2026Review
- A Hypothalamic Oxytocinergic-Sympathetic Axis Couples Anxiety Dysregulation With Impaired Tendon-Bone Repair.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Stage-Specific Effects of Maternal Circadian Rhythm Disruption during Pre-Pregnancy, Pregnancy, and Lactation on Behavioral and Neurobiological Outcomes in Male Rat Offspring.Molecular neurobiology · 2026Article
- Hypothalamic oxytocin neurons produce pro-anxiety effects through glutamatergic projections to the lateral hypothalamus.Cell discovery · 2026Article
- Oxytocin promotes socially triggered cataplexy.Nature neuroscience · 2026Article
- Norepinephrinergic projection from locus coeruleus to parafascicular nucleus promotes pain and anxiety-like behaviors in mice.JCI insight · 2026Article
- Mrgprb4-Lineage Neurons Participate in the Intervention of TENS Effects on Chronic Pain and Anxiety-like Symptoms in an Inflammatory Pain Mouse Model.Biomedicines · 2026Article
- The pPVTThe journal of headache and pain · 2026Article
- Acute and chronic stress differentially regulate pain via distinct ensembles in the paraventricular nucleus of hypothalamus.Molecular psychiatry · 2026Article
- Recent progress in chronic pain-related negative emotions and cognitive dysfunction: insights into the mechanisms underlying neural circuitry.Frontiers in cellular neuroscience · 2026Review
- Distinct and Shared Brain-Wide Activation Patterns in Mouse Models of Inflammatory and Neuropathic Pain.Journal of pain research · 2026Article
- Adipose Tissue and Central Nervous System Crosstalk: Roles in Pain and Cognitive Dysfunction.Biomedicines · 2025Review
- Activation of the C3 Complement Pathway in the Hippocampus Produces Anxiodepressive Effects in a Mouse Model of Inflammation Pain.Molecular neurobiology · 2025Article
- Longitudinal relationship between anxiety and sleep quality in community residents: the mediating effect of loneliness.BMC psychiatry · 2025Article
- Leveraging Fiber Photometry to Decipher Neural Circuits Underlying Anxiety in Mice.Fundamental & clinical pharmacology · 2025Review
- Astrocyte inhibition and PV interneuron activation: key mechanisms in electroacupuncture's effect on pain-anxiety comorbidity.Chinese medicine · 2025Article
- Compromised PGF2α signaling in the paraventricular hypothalamic nucleus contributes to the central sensitization of the nitroglycerin-induced chronic migraine in male mice.The journal of headache and pain · 2025Article
- Complexity of the Hypothalamic Oxytocin System and its Involvement in Brain Functions and Diseases.Neuroscience bulletin · 2025Review
- Dorsal raphe GABA-ergic neurons regulate the susceptibility to social transfer of pain in mice.Acta pharmacologica Sinica · 2025Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsAnxiety disorders associated with pain are a common health problem. However, the underlying mechanisms remain poorly understood. We aimed to investigate the role of paraventricular nucleus (PVN)-central nucleus of the amygdala (CeA) oxytocinergic projections in anxiety-like behaviors induced by inflammatory pain.
methodsAfter inflammatory pain induction by complete Freund's adjuvant (CFA), mice underwent elevated plus maze, light-dark transition test, and marble burying test to examine the anxiety-like behaviors. Chemogenetic, optogenetic, and fiber photometry recordings were used to modulate and record the activity of the oxytocinergic projections of the PVN-CeA.
resultsThe key results are as follows: inflammatory pain-induced anxiety-like behaviors in mice accompanied by decreased activity of PVN oxytocin neurons. Chemogenetic activation of PVN oxytocin neurons prevented pain-related anxiety-like behaviors, whereas inhibition of PVN oxytocin neurons induced anxiety-like behaviors in naïve mice. PVN oxytocin neurons projected directly to the CeA, and microinjection of oxytocin into the CeA blocked anxiety-like behaviors. Inflammatory pain also decreased the activity of CeA neurons, and optogenetic activation of PVN
conclusionThe results of our study suggest that oxytocin has anti-anxiety effects and provide novel insights into the role of PVN
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