SynthesisNature genetics2023
Genome-wide association meta-analysis of spontaneous coronary artery dissection identifies risk variants and genes related to artery integrity and tissue-mediated coagulation.
Registry-linked trialOpen access · hybridAbstract readMeta-Analysis
In one paragraph
Synthesis in Nature genetics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01427179 (Genetic Investigations in Spontaneous Coronary Artery Dissection), which is not on this map. Cited by 52 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 2 pooled it
16.7field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Genetic Investigations in Spontaneous Coronary Artery Dissection (SCAD)
Who cites it
52 citing papers in PubMed, 2 syntheses or guidelines pooled it, 78 citations in OpenAlex.
- Integrative Genome-wide Association Meta-analysis of Aortic Aneurysm and Dissection Identifies Five Novel Genes.Genomics, proteomics & bioinformatics · 2025Pooled it
- Exploring associations between estrogen and gene candidates identified by coronary artery disease genome-wide association studies.Frontiers in cardiovascular medicine · 2025Pooled it
- Redesigning cardiovascular medicine around sex differences.Nature medicine · 2026Review
- Spontaneous Coronary Artery Dissection and Takotsubo Syndrome: Converging Mechanisms, Diagnostic Pitfalls, and a Unified Clinical Algorithm.Journal of clinical medicine · 2026Review
- Integrated Single-Cell and Spatial Analysis Reveals a Metabolic-Immune Axis Driving Aortic Dissection.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Myocardial Infarction With Non-Obstructive Coronary Artery Disease: Exploration of the Etiology to Guide Therapy.Reviews in cardiovascular medicine · 2026Review
- Gene Expression Profiles at Early vs Late Stages After Cervical Artery Dissection.Neurology. Genetics · 2026Article
- ZNF827 pleiotropic cardiovascular risk locus involves regulation by nuclear factor-1.Clinical science (London, England : 1979) · 2026Article
- Spontaneous Coronary Artery Dissection: Advances in Understanding and Management in Women.Current atherosclerosis reports · 2026Review
- A Contemporary Review of Spontaneous Coronary Artery Dissection: CLINICAL CARE, CARDIAC REHABILITATION, AND FUTURE DIRECTIONS.Journal of cardiopulmonary rehabilitation and prevention · 2026Review
- Multi-trait and Gene-Based Analyses Identify Genetic Variants Associated with Spontaneous Coronary Artery Dissection.medRxiv : the preprint server for health sciences · 2026Article
- On the provenance of spontaneous coronary artery dissection.European heart journal open · 2026Review
- Genetic Association of Circulating Proteins and Gene Transcripts With Spontaneous Coronary Artery Dissection.Circulation. Genomic and precision medicine · 2026Article
- Cardiovascular complications of pregnancy.The Journal of clinical investigation · 2026Review
- Spontaneous coronary artery dissection as a threshold disorder of coronary wall integrity.Frontiers in cardiovascular medicine · 2026Review
- Spontaneous coronary artery dissection: dissecting an underdiagnosed problem.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2025Review
- Unraveling Spontaneous Coronary Artery Dissection in Sudden Cardiac Death: Integrating Pathology, Genetics, and Molecular Autopsy.International journal of molecular sciences · 2025Review
- Two separate episodes of spontaneous coronary artery dissection in a patient with familial spontaneous coronary artery dissection background: a case report.European heart journal. Case reports · 2025Article
- A genetic map of human metabolism across the allele frequency spectrum.Nature genetics · 2025Article
- Spontaneous Coronary Artery Dissection (SCAD): Unveiling the Enigma of the Unexpected Coronary Event.Current atherosclerosis reports · 2025Review
Corrections and comments
- Commented on by
Authors and funding
56 authors at 18 institutions in 7 countries.
David Adlam *Department of Cardiovascular Sciences, Glenfield Hospital, Leicester, UK. da134@leicester.ac.uk.ORCID 0000-0002-0080-9884
Takiy-Eddine Berrandou *Université Paris Cité, Paris Cardiovascular Research Center, Inserm, Paris, France.ORCID 0000-0002-0525-3002
Adrien Georges *Université Paris Cité, Paris Cardiovascular Research Center, Inserm, Paris, France.ORCID 0000-0003-4208-2393
Christopher P NelsonDepartment of Cardiovascular Sciences, Glenfield Hospital, Leicester, UK.ORCID 0000-0001-8025-2897
Eleni GiannoulatouVictor Chang Cardiac Research Institute, Sydney, New South Wales, Australia.
Joséphine HenryUniversité Paris Cité, Paris Cardiovascular Research Center, Inserm, Paris, France.
Lijiang MaDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Montgomery BlencoweDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA, USA.
Tamiel N TurleyMayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic, Rochester, MN, USA.
Min-Lee YangDivision of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.
Sandesh ChopadeInstitute for Cardiovascular Science, University College London, London, UK.
Chris FinanInstitute for Cardiovascular Science, University College London, London, UK.ORCID 0000-0002-3319-1937
Peter S BraundDepartment of Cardiovascular Sciences, Glenfield Hospital, Leicester, UK.ORCID 0000-0001-8540-5709
Ines Sadeg-SayoudUniversité Paris Cité, Paris Cardiovascular Research Center, Inserm, Paris, France.
Siiri E IismaaVictor Chang Cardiac Research Institute, Sydney, New South Wales, Australia.ORCID 0000-0003-2409-7356
Matthew L KoselDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.
Xiang ZhouDepartment of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.ORCID 0000-0002-4331-7599
Stephen E HambyDepartment of Cardiovascular Sciences, Glenfield Hospital, Leicester, UK.ORCID 0000-0002-6215-5791
Jenny ChengDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA, USA.
Lu LiuUniversité Paris Cité, Paris Cardiovascular Research Center, Inserm, Paris, France.
Ingrid TarrVictor Chang Cardiac Research Institute, Sydney, New South Wales, Australia.
David W M MullerVictor Chang Cardiac Research Institute, Sydney, New South Wales, Australia.ORCID 0000-0002-5281-0166
Valentina d'EscamardCardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Annette KingZena and Michael A. Wiener Cardiovascular Institute and Marie-Josée and Henry R. Kravis Center for Cardiovascular Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Liam R BrunhamCentre for Heart Lung Innovation, Departments of Medicine and Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada.ORCID 0000-0002-3686-3807
Ania A Baranowska-ClarkeDepartment of Cardiovascular Sciences, Glenfield Hospital, Leicester, UK.
Stéphanie DebetteDepartment of Neurology, Bordeaux University Hospital, Inserm, Bordeaux, France.ORCID 0000-0001-8675-7968
Philippe AmouyelUniversité de Lille, Inserm, CHU Lille, Institut Pasteur de Lille, RID-AGE - Labex DISTALZ - Risk Factors and Molecular Determinants of Aging-Related Disease, Lille, France.ORCID 0000-0001-9088-234X
Jeffrey W OlinZena and Michael A. Wiener Cardiovascular Institute and Marie-Josée and Henry R. Kravis Center for Cardiovascular Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0003-3374-616X
Snehal PatilDepartment of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Stephanie E HesselsonVictor Chang Cardiac Research Institute, Sydney, New South Wales, Australia.ORCID 0000-0002-4521-5086
Keerat JundayVictor Chang Cardiac Research Institute, Sydney, New South Wales, Australia.
Stavroula KanoniWilliam Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.ORCID 0000-0002-1691-9615
Krishna G AragamCardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0003-3223-9131
Adam S ButterworthBritish Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.ORCID 0000-0002-6915-9015
CARDIoGRAMPlusC4D
MEGASTROKE
International Stroke Genetics Consortium (ISGC) Intracranial Aneurysm Working Group
Marysia S TweetDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.
Rajiv GulatiDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.
Nicolas CombaretDepartment of Cardiology, CHU Clermont-Ferrand, CNRS, Université Clermont Auvergne, Clermont-Ferrand, France.ORCID 0000-0003-4905-0765
DISCO register
Daniella Kadian-DodovZena and Michael A. Wiener Cardiovascular Institute and Marie-Josée and Henry R. Kravis Center for Cardiovascular Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Jonathan M KalmanDepartment of Cardiology, Royal Melbourne Hospital, Melbourne, Victoria, Australia.
Diane FatkinVictor Chang Cardiac Research Institute, Sydney, New South Wales, Australia.ORCID 0000-0002-9010-9856
Aroon D HingoraniInstitute for Cardiovascular Science, University College London, London, UK.ORCID 0000-0001-8365-0081
Jacqueline SawVancouver General Hospital, Division of Cardiology, University of British Columbia, Vancouver, British Columbia, Canada.ORCID 0000-0002-7027-984X
Tom R WebbDepartment of Cardiovascular Sciences, Glenfield Hospital, Leicester, UK.ORCID 0000-0001-5998-8226
Sharonne N HayesDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0003-3129-362X
Xia YangDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0002-3971-038X
Santhi K GaneshDivision of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.
Timothy M OlsonDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0003-2716-9423
Jason C KovacicVictor Chang Cardiac Research Institute, Sydney, New South Wales, Australia.ORCID 0000-0003-4555-769X
Robert M GrahamVictor Chang Cardiac Research Institute, Sydney, New South Wales, Australia.ORCID 0000-0002-1042-2587
Nilesh J SamaniDepartment of Cardiovascular Sciences, Glenfield Hospital, Leicester, UK.
Nabila Bouatia-NajiUniversité Paris Cité, Paris Cardiovascular Research Center, Inserm, Paris, France. nabila.bouatia-naji@inserm.fr.ORCID 0000-0001-5424-2134
Victor Chang Cardiac Research Institute · AUInserm · FRGlenfield Hospital · GBCardiovascular Institute of the South · USUniversity of Michigan · USUtrecht University · NLBritish Heart Foundation · GBCentre National de la Recherche Scientifique · FRIcahn School of Medicine at Mount Sinai · USMayo Clinic in Arizona · USQB3 · USUniversity of California, Los Angeles · USBroad Institute · USMayo Clinic in Florida · USQueen Mary University of London · GBThe Royal Melbourne Hospital · AUUniversity of British Columbia · CAUniversity of Cambridge · GB
Funding
Genome-Wide Association Analysis in Essential Hypertension (FEHGAS study)R01HL086694 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ARAVINDA CHAKRAVARTI · 2007 to 2026
$21.2MGenomic and Functional Studies of Dysplasia-Associated Arterial DiseasesR35HL161016 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SANTHI K GANESH · 2022 to 2026
$4.6MSystems Genetics Dissection of Non-alcoholic SteatohepatitisR01DK117850 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Aldons Jake Lusis · 2019 to 2026
$4.6MSystems genetics approach to inflammatory mechanisms in atherosclerosisR01HL147883 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LUSIS, ALDONS JAKE · 2019 to 2022
$3.0MGenetic and Genomic Analysis of Arterial DysplasiaR01HL139672 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GANESH, SANTHI K · 2018 to 2021
$2.9MUnderstanding the Molecular Mechanisms of Fibromuscular DysplasiaR01HL148167 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KADIAN-DODOV, DANIELLA, KOVACIC, JASON CIRIL · 2020 to 2023
$2.8MPredoctoral Training Program in Molecular PharmacologyT32GM072474 · NIGMS · MAYO CLINIC ROCHESTER · PI KARNITZ, LARRY M · 2005 to 2020
$2.4MThe Vascular, Autonomic, and Myocardial Phenotypes in Women with Myocardial Infarction due to Spontaneous Coronary Artery DissectionK23HL155506 · NHLBI · MAYO CLINIC ROCHESTER · PI Marysia S Tweet · 2021 to 2026
$808kAmerican Heart Association-American Stroke Association 829009British Heart Foundation PG/13/96/30608British Heart Foundation SP/16/4/32697Department of HealthEuropean Research Council 716628NHLBI NIH HHS K23 HL155506NHLBI NIH HHS R01 HL086694NHLBI NIH HHS R01 HL139672NHLBI NIH HHS R01 HL147883NHLBI NIH HHS R01 HL148167NHLBI NIH HHS R35 HL161016NIDDK NIH HHS R01 DK117850NIGMS NIH HHS T32 GM072474NIH HHS R01HL139672NIH HHS R01HL147883NIH HHS R01HL148167NIH HHS R35HL161016NIH HHS T32 GM72474
Abstract
Spontaneous coronary artery dissection (SCAD) is an understudied cause of myocardial infarction primarily affecting women. It is not known to what extent SCAD is genetically distinct from other cardiovascular diseases, including atherosclerotic coronary artery disease (CAD). Here we present a genome-wide association meta-analysis (1,917 cases and 9,292 controls) identifying 16 risk loci for SCAD. Integrative functional annotations prioritized genes that are likely to be regulated in vascular smooth muscle cells and artery fibroblasts and implicated in extracellular matrix biology. One locus containing the tissue factor gene F3, which is involved in blood coagulation cascade initiation, appears to be specific for SCAD risk. Several associated variants have diametrically opposite associations with CAD, suggesting that shared biological processes contribute to both diseases, but through different mechanisms. We also infer a causal role for high blood pressure in SCAD. Our findings provide novel pathophysiological insights involving arterial integrity and tissue-mediated coagulation in SCAD and set the stage for future specific therapeutics and preventions.
Indexed as
Coronary Artery DiseaseMyocardial InfarctionVascular DiseasesCoronary Vessel AnomaliesFemaleGenome-Wide Association StudyHumans
Identifiers
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LicenceCC BY
Read underepoch 390
Registered trials
NCT01427179ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.