Evidence map›Paper›PMID 37248370›Full record

Observational studyTechniques in coloproctology2023

Epidemiology, oncologic results and risk stratification model for metachronous peritoneal metastases after surgery for pT4 colon cancers: results from an observational retrospective multicentre long-term follow-up study.

C Cerdán-Santacruz, Ó Cano-Valderrama, E Peña Ros, Á Serrano Del Moral, F Pereira Pérez, B Flor Lorente, S Biondo, Collaborating group for the study of metachronous peritoneal metastases of pT4 colon cancer

Abstract readObservational StudyMulticenter Study
PubMed Publisher
In one paragraph

Observational study in Techniques in coloproctology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 1 country.

C Cerdán-Santacruz *Colorectal Surgery Department, Hospital Universitario de la Princesa, Diego de León, 62, 28006, Madrid, Spain. carloscerdansantacruz@hotmail.com.ORCID 0000-0002-6507-900X
Ó Cano-Valderrama *Colorectal Surgery Department, Complejo Hospitalario Universitario de Vigo, Vigo, Spain.ORCID 0000-0003-0775-6217
E Peña RosColorectal Surgery Department, Hospital Reina Sofía, Murcia, Spain.ORCID 0000-0003-2230-2125
Á Serrano Del MoralColorectal Surgery Department, Hospital de Fuenlabrada, Madrid, Spain.ORCID 0000-0001-6354-5022
F Pereira PérezGeneral Surgery Department, Hospital de Fuenlabrada, Madrid, Spain.ORCID 0000-0002-9976-5112
B Flor LorenteColorectal Surgery Department, Hospital Universitario y Politécnico la Fe, Valencia, Spain.ORCID 0000-0002-3399-9477
S BiondoDepartment of General and Digestive Surgery, Bellvitge University Hospital, University of Barcelona and IDIBELL, Barcelona, Spain.ORCID 0000-0002-7374-0371
Collaborating group for the study of metachronous peritoneal metastases of pT4 colon cancer
Hospital Reina Sofía de Murcia · ESHospital Universitario de Fuenlabrada · ESBellvitge University Hospital · ESHospital Universitari i Politècnic La Fe · ESHospital Universitario de La Princesa · ESUniversity Hospital Complex Of Vigo · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeMetachronous peritoneal metastases (MPM) following a curative surgery procedure for pT4 colon cancer is a challenging condition. Current epidemiological studies on this topic are scarce.

methodsA retrospective multicentre trial was designed. All consecutive patients who underwent operations to treat pT4 cancers between 2015 and 2017 were reviewed. Demographic, clinical, operative, pathological and oncological follow-up variables were included. MPM were described as any oncological disease at the peritoneum, clearly different from a local recurrence. Univariate and multivariate Cox regression models were constructed. A risk stratification model was created on a cumulative factor basis. According to the calculated hazard ratio (HR), a scoring system was designed (HR < 3, 1 point; HR > 3, 2 points) and a scale from 0 to 6 was calculated for peritoneal disease-free rate (PDF-R). A risk stratification model was also created on the basis of these calculations.

resultsFifty different hospitals were involved, which included a total of 1356 patients. Incidence of MPM was 13.6% at 50 months median follow-up. The strongest independent risk factors for MPM were positive pN stage [HR 3.72 (95% CI 2.56-5.41; p < 0.01) for stage III disease], tumour perforation [HR 1.91 (95% CI 1.26-2.87; p < 0.01)], mucinous or signet ring cell histology [HR 1.68 (95% CI 1.1-2.58; p = 0.02)], poorly differentiated tumours [HR 1.54 (95% CI 1.1-2.2; p = 0.02)] and emergency surgery [HR 1.42 (95% CI 1.01-2.01; p = 0.049)]. In the absence of additional risk factors, pT4 tumours showed 98% and 96% PDF-R in 1-year and 5-year periods based on Kaplan-Meier curves.

conclusionsCumulative MPM incidence was 13.6% at 5-year follow-up. The sole presence of a pT4 tumour resulted in high rates of PDF-R at 1-year and 5-year follow-up (98% and 96% respectively). Five additional risk factors different from pT4 status itself were identified as possible MPM indicators during follow-up.

Indexed as

Colonic NeoplasmsPeritoneal NeoplasmsFollow-Up StudiesHumansPeritoneumPrognosisRetrospective StudiesRisk AssessmentColon cancerHIPECMetachronous peritoneal metastasesRisk stratificationSecond look

Identifiers

PMID37248370
OpenAlexW4378647251

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.